Abstract
While an inorganic mercury compound was excreted in rats via bile with substances of high molecular weight only (fraction 1), MeHg and PhHg compounds were excreted with substances of both high and low (fraction 2) molecular weights. The rate of enterohepatic circulation of the compounds increased and their total excretion from rats decreased with the relatively higher content of the compounds in fraction 2. The bile composition was found to be changed as a result of intoxication by organomercury compounds.
Zusammenfassung
Während anorganische Quecksilberverbindungen durch die Galle der Ratten nur mit Gallenkomponenten von hohem Molekulargewicht ausgeschieden werden (Fraktion 1), wurden die MeHg- und PhHg-Verbindungen mit Gallenkomponenten von sowohl hohen als auch niedrigen (Fraktion 2) Molekulargewichten ausgeschieden. Die Geschwindikgeit der enterohepatischen Zirkulation dieser Verbindungen vergrößerte sich und deren Gesamtausscheidung verringerte sich mit relativ höheren Inhalt der Verbindung in Fraktion 2. Die Zusammensetzung der Galle war in Folge der Vergiftung durch organische Quecksilberverbindung geändert.
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Tichý, M., Havrdová, J. & Cikrt, M. Comments on the mechanism of excretion of mercury compounds via bile in rats. Arch Toxicol 33, 267–271 (1975). https://doi.org/10.1007/BF00311279
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DOI: https://doi.org/10.1007/BF00311279