Zusammenfassung
In einem Fall von akuter Parathion-Intoxikation, welcher 9 Tage überlebte, wurden bei der Autopsie segmentale Nekrosen in der Nähe der motorischen Endplatten in den Zwerchfellmuskelfasern gefunden. Obwohl die nekrotischen Veränderungen nur am Zwerchfell gefunden wurden, fehlte die Cholinesteraseaktivität auch in allen übrigen untersuchten Muskelendplatten. Die Nekrose im Endplattenbereich des immer noch beweglichen Zwerchfelles war wahrscheinlich eine Folge der langdauernden Depolarisation mit Veränderungen der postsynaptischen Membran als Ergebnis der hohen Acetylcholinkonzentration.
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De Reuck, J., Willems, J. Acute parathion poisoning: Myopathic changes in the diaphragm. J Neurol. 208, 309–314 (1975). https://doi.org/10.1007/BF00312805
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DOI: https://doi.org/10.1007/BF00312805