Summary
Postural instability was measured and short, medium and long latency EMG responses to angular displacement of the ankle were recorded from leg muscles in a group of 17 alcoholics who presented with clinical signs of cerebellar atrophy of the anterior lobe. Recordings were performed twice (average interval 18.5 months) to determine the effects of continued drinking versus abstinence on the signs of the cerebellar damage. Patients who were abstinent (n=11) exhibited a significant, sometimes dramatic decrease of body sway whereas patients who continued drinking (n=6) showed increased body sway when the eyes were closed. Short and medium latency EMG responses were unaltered in both groups of patients. The integral of the long latency response of the antagonist tended to increase with continued abuse and to decrease in abstinent patients.
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References
Adams A (1976) Nutritional cerebellar degeneration. In: Vinken PJ, Bruyn GW (eds) Metabolic and deficiency diseases of the nervous system. Handbook of clinical neurology, vol 28. Elsevier, Amsterdam, pp 271–283
Allsop J, Turner B (1966) Cerebellar degeneration associated with chronic alcoholisms. J Neurol Sci 3:238–258
Allum JHJ, Büdingen JH (1979) Coupled stretch reflexes in ankle muscles: an evaluation of the contribution of active muscle mechanisms to human postural stability. Prog Brain Res 50:185–195
Decker JB, Wells CE, McDowell F (1959) Cerebellar dysfunction associated with chronic alcoholism. Neurology (Minneap) 9:361–366
Dichgans J, Mauritz KH, Allum JHJ, Brandt TH (1976) Postural sway in normals and atactic patients: analysis of the stabilizing and destabilizing effects of vision. Agressologie 17C:15–24
Diener HC, Bootz F, Dichgans J, Bruzek W (1983) Variability of postural “reflexes” in humans. Exp Brain Res 52:423–428
Diener HC, Dichgans J, Bacher M, Gompf B (1984) Quantification of postural sway in normals and patients with cerebellar diseases. Electroencephalogr Clin Neurophysiol 57:134–142
Diener HC, Dichgans J, Bacher M, Guschlbauer B (1984) Characteristic alterations of long-loop “reflexes” in patients with Friedreich's disease and late atrophy of the cerebellar anterior lobe. J Neurol Neurosurg Psychiatry 47:679–685
Dixon WJ, Mood AM (1946) The statistical sign test. J Am Stat Assoc 41:557–566
Mancall EL (1975) Late (acquired) cortical cerebellar atrophy. In: Vinken PJ, Bruyn GW (eds) System disorders and atrophies. Handbook of clinical neurology, vol 21. Elsevier, Amsterdam, pp 477–508
Mauritz KH, Dichgans J, Hufschmidt A (1979) Quantitative analysis of stance in late cortical cerebellar atrophy of the anterior lobe and other forms of cerebellar ataxia. Brain 102:461–482
Mauritz KH, Schmitt C, Dichgans J (1981) Delayed and enhanced long latency reflexes as the possible cause of postural tremor in late cerebellar atrophy. Brain 104:97–116
Ron MA, Acker W, Shaw GK, Lishman WA (1982) Computerized tomography of the brain in chronic alcoholism. A survey and follow-up study. Brain 105:497–514
Silfverskiöld BP (1977a) Cortical cerebellar degeneration associated with a specific disorder of standing and locomotion. Acta Neurol Scand 55:257–272
Silfverskiöld BP (1977b) A 3c/sec leg tremor in a “cerebellar” syndrome. Acta Neurol Scand 55:385–393
Stork J (1967) Kleinhirnwurmatrophie und chronischer Alkoholismus. Schweiz Arch Neurol Neurochir Psychiatr 99:40–82
Thomas A (1905) Atrophie lamellaire de cellules de Purkinje. Rev Neurol (Paris) 13:917–924
Torvik A, Lindboe CF, Rogde S (1982) Brain lesions in alcoholics. J Neurol Sci 56:233–248
Victor M, Adams RD, Mancall EL (1959) A restricted form of cerebellar cortical degeneration occurring in alcoholic patients. Arch Neurol 1:579–688
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Diener, H.C., Dichgans, J., Bacher, M. et al. Improvement of ataxia in alcoholic cerebellar atrophy through alcohol abstinence. J Neurol 231, 258–262 (1984). https://doi.org/10.1007/BF00313662
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DOI: https://doi.org/10.1007/BF00313662