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Regional cerebral blood flow and blood volume measured with the gamma camera

Le flux sanguin cerebral regional et le volume sanguin mesure a l'aide de la gamma-camera

Regionaler cerebraler Blutdurchfluß- und Blutvolumen-Messungen mit der Gamma-Camera

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Summary

Regional cerebral blood flow (rCBF), hemispheric blood flow (HBF), extracranial blood flow, and regional cerebral blood volume (rCBV) have been measured in a series of patients using a gamma camera equipped with a magnetic tape system for storage and retrieval. This method eliminates the need for multiple probes in measuring these parameters. 133Xe and 99m Tc injected into the carotid arteries were used as radioactive indicators. These measurements were carried out in patients with cerebral infarction, intracerebral hematoma, brain tumor, arteriovenous malformation, and dementia. The HBF values obtained with this method were in excellent agreement with those using the hydrogen bolus method in the same patients. The effects of 5% CO2 inhalation, intravenous infusion of glycerol, and vasodilator drugs on rCBF and rCBV were evaluated and were found useful from diagnostic and therapeutic points of view. “Intracerebral steal” or “intracerebral squeeze” were demonstrated only in patients with space-occupying lesions such as intracerebral hematoma or brain tumor. Cerebral revascularization using a recently developed intracranial bypass procedure for the occluded internal carotid artery was found effective in increasing rCBF in selected cases where the procedure was successful.

Résumé

Le flux sanguin cérébral régional, le flux sanguin hémisphérique, le flux sanguin extracrânien et le volume sanguin cérébral régional ont été mesurés chez une série de malades á l'aide de la gamma-caméra munie d'un système de bandes magnétiques pour enregistrement et relecture. Cette méthode élimine la nécessité de multiples essais pour mesurer ces paramètres. Le 133Xe et le 99mTc injectés dans les artères carotides servent d'indicateurs radio-actifs. Ces mesures ont été effectuées chez des patients atteints de ramollissement cérébral, d'hématome intracérébral, de tumeur cérébrale, de malformation artério-veineuse et de démence. Les valeurs du flux sanguin cérébral hémisphérique correspondaient á celles obtenues par la technique de l'embol á hydrogène. Les effets d'inhalateurs de CO2 á 5%, de perfusions intraveineuses de Glycérol et de vaso-dilatateurs sur le flux cérébral régional ont été déterminés et trouvés intéressants pour le point de vue diagnostique et thérapeutique. Des dérivations de sang ont été trouvées chez des malades atteints de lésions expansives (hématomes et tumeurs). Dans le cas de thrombose de la carotide interne, les mesures montrent une augmentation du glux sanguin cérébral régional lorsqu'une intervention par bypass est mise en oeuvre.

Zusammenfassung

Nach Injektion von Xe 133 und Tc 99m in die A. carotis wurden der regionale cerebrale Blutdurchfluß und der Hemisphärenblutdurchfluß mit der Gamma-Camera bestimmt. Dabei konnten die gleichen Ergebnisse wie mit den übrigen punktförmigen Messungen nachgewiesen werden.

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Authors and Affiliations

  1. Department of Neurology, Baylor College of Medicine, the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas, U.S.A.

    N. T. Mathew, J. S. Meyer, R. L. Bell, P. C. Johnson & C. R. Neblett

  2. Radioisotope Department, The Methodist Hospital, Houston, Texas, U.S.A.

    N. T. Mathew, J. S. Meyer, R. L. Bell, P. C. Johnson & C. R. Neblett

Authors
  1. N. T. Mathew
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  2. J. S. Meyer
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  3. R. L. Bell
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  4. P. C. Johnson
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  5. C. R. Neblett
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Additional information

Supported by Grant No. NS 09287-02 from the National Institute of Neurological Diseases and Stroke, National Institutes of Health, U.S. Public Health Service.

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Mathew, N.T., Meyer, J.S., Bell, R.L. et al. Regional cerebral blood flow and blood volume measured with the gamma camera. Neuroradiology 4, 133–140 (1972). https://doi.org/10.1007/BF00327578

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