Abstract
The effect of the H-2 dm1 mutation on Qa-m2 expression was examined. The mutant strain B10.D2-H-2 dm1 showed a fourfold increase in Qa-m2 expression when compared with the parental strain B10.D2. Qa-m2 molecules immunoprecipitated from B10.D2-H-2 dm1, C57BL/10, and B10.D2 spleen cells were identical by two-dimensional (2-D) gel electrophoresis [isoelectric focusing (IEF) followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)]. It is likely therefore that the increased Qa-m2 expression is not due to gross structural alterations of the Qa-m2 molecule; in the present study, alternative explanations are discussed.
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Hogarth, P.M., Walker, I.D., Rigby, A.J. et al. The H-2 dm1mutation and Qa antigens. Immunogenetics 18, 617–624 (1983). https://doi.org/10.1007/BF00345969
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DOI: https://doi.org/10.1007/BF00345969