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Hydrothermal synthesis of biocompatible whiskers

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Abstract

The preparation of non-toxic and biocompatible fibres or whiskers is one of the most urgent tasks today, because most of the fibrous materials which have been used (including asbestos which has been used for many years) are thought to be biohazardous. Whiskers of hydroxyapatite (Ca10(PO4)6(OH)2∶HAp), which is expected to be one of the best biocompatible materials, have been successfully synthesized by hydrothermal treatments of beta-tricalcium phosphate (beta-Ca3(PO4)2: beta-TCP) with citric acid. These whiskers were single crystals, elongated along the c-axis, with a length of 20–30 μm and a width of 0.1–1 μm. They were slightly calcium deficient (Ca/P molar ratio = 1.63) and they contained a trace of CO 2−3 in their structure.

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References

  1. B. T. Mossman, J. Bignon, M. Corn, A. Seaton and J. B. L. Gee, Science 247 (1990) 294.

    Article  CAS  Google Scholar 

  2. L. Michaels and S. S. Chissick (editors) “Asbestos, Vol. 1, Properties, applications, and hazards” (Wiley, New York, 1979).

    Google Scholar 

  3. M. F. Stanton, M. Layard, A. Tegerin, F. Miller, M. May, E. Morgan and A. Smith, J. Natl. Cancer Inst. 67 (1981) 965.

    CAS  Google Scholar 

  4. F. Pott, Staub-Reinh. Luft, 38 (1978) 486.

    CAS  Google Scholar 

  5. J. V. Milewski, F. D. Gac, J. J. Petrovic and S. R. Skaggs, J. Mater. Sci. 20 (1985) 1160.

    Article  CAS  Google Scholar 

  6. H. Murayama and T. Maeda, Nature 345 (1990) 791.

    Article  CAS  Google Scholar 

  7. G. E. Legrov, T. F. Lim, J. Lipowitz and R. S. Reaoch, Amer. Ceram. Soc. Bull. 66 (1987) 363.

    Google Scholar 

  8. T. Oota, H. Saito and I. Yamai, J. Cryst. Growth, 46 (1979) 331.

    Article  CAS  Google Scholar 

  9. S. Jagota and R. Rouj, ibid. 85 (1987) 527.

    Article  CAS  Google Scholar 

  10. M. Egashira, H. Katsuki, S. Takatsuki and H. Iwanaga, Yogyo-Kyokai-shi (in Japanese) 95 (1987) 138.

    Article  CAS  Google Scholar 

  11. I. Matsubara, H. Tanigawa, T. Ogura, H. Yamashita, M. Kinoshita and T. Kawai, Jpn. J. Appl. Phys. 28 (1989) L1121.

    Article  CAS  Google Scholar 

  12. H. Aoki, “Science and medical applications of hydroxyapatite (Japanese Association of Apatite Science, (1991).

  13. P. Ducheyne, J. Biomed. Mater. Res.: Applied Biomater. (editors) A 21, (1987) 219.

    Google Scholar 

  14. P. Ducheyne, T. Kokubo and C. A. Van blitterswijk (editors) “Bone-bonding biomaterials” (Reed Healthcare Communications, 1992).

  15. A. Mortier, J. Lemaitre, L. Rodrique and P. Rouxhet, J. Solid State Chem. 78 (1989) 215.

    Article  CAS  Google Scholar 

  16. M. Kinoshita, A. Kishioka, H. Hayashi and S. Itatani, Gypsum, Lime 219 (1989) 23.

    Google Scholar 

  17. N. Christiansen and R. E. Riman, Proceedings of the 5th. Scandinavian Symposium on Materials Science (1989) pp. 209–220.

  18. B. O. Fowler, Inorg. Chem. 13 (1974) 207.

    Article  CAS  Google Scholar 

  19. E. C. Moreno, T. M. Gregory and W. E. Brown, J. Res. Nat. Bur. Stand. A 72 (1968) 773.

    Article  CAS  Google Scholar 

  20. A. Perloff and A. S. Posner, Science 124 (1956) 583.

    Article  CAS  Google Scholar 

  21. K. Ioku, M. Yoshimura and S. Somiya, Nippon Kagaku Kaishi 9 (1988) 1565.

    Article  Google Scholar 

  22. S. Somiya, K. Ioku and M. Yoshimura, Mater. Sci. Forum 34–36 (1988) 371–378.

    Google Scholar 

  23. M. Yoshimura, H. Suda, K. Okamoto and K. Ioku, Nippon Kagaku Kaishi 10 (1991) 3101.

    Google Scholar 

  24. N. Asaoka, H. Suda and M. Yoshimura, submitted to Nippon Kagaki Kaishi.

  25. N. Balmain, R. Legeros and G. Bonel, Calcif. Tissue Int. 34 (1982) S93.

    Google Scholar 

  26. H. Suda, N. Asaoka and M. Yoshimura, in “Bioceramics Vol. 5, Proceedings of the 5th International Symposium on Ceramics in Medicine”, edited by T. Yamamuro, T. Kokubo and T. Nakamura (Kobunsha Kankokai, 1992) pp. 31–34.

  27. T. Kawasaki, J. Chromatogr. 544 (1991) 144.

    Article  Google Scholar 

  28. D. R. Simpson, Amer. Miner. 53 (1968) 432.

    CAS  Google Scholar 

  29. US Environmental Protection Agency, Report to Congress, Study of Asbestos-Containing Materials in Public Buildings (US Environmental Protection Agency, Washington, DC, February 1988), p. 5.

    Google Scholar 

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Authors and Affiliations

  1. Research Laboratory of Engineering Materials, Tokyo Institute of Technology, 4259 Nagatsuta-cho Midori-ku, 227, Yokohama, Japan

    Masahiro Yoshimura & Hiroyuki Suda

  2. Mitsubishi Materials Co. Ltd., 2270 Yokoze-cho, 368, Chichibu-gun, Japan

    Kengo Okamoto

  3. Faculty of Engineering, Yamaguchi University, 2557 Tokiwadáe, 755, Ube, Japan

    Koji Ioku

Authors
  1. Masahiro Yoshimura
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  2. Hiroyuki Suda
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  3. Kengo Okamoto
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  4. Koji Ioku
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Yoshimura, M., Suda, H., Okamoto, K. et al. Hydrothermal synthesis of biocompatible whiskers. JOURNAL OF MATERIALS SCIENCE 29, 3399–3402 (1994). https://doi.org/10.1007/BF00352039

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  • DOI: https://doi.org/10.1007/BF00352039

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