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The mouse Fc receptor for IgG (Ly-17) : molecular cloning and specificity

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Abstract

A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional FcγR investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgGγ1/2b and rabbit IgG complexes.

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Authors and Affiliations

  1. Research Centre for Cancer and Transplantation, University of Melbourne, Grattan St., 3052, Parkville, Australia

    P. Mark Hogarth, Margaret L. Hibbs, Lisa Bonadonna, Bernadette M. Scott, Ewa Witort, Geoffrey A. Pietersz & Ian F. C. McKenzie

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  1. P. Mark Hogarth
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  2. Margaret L. Hibbs
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  3. Lisa Bonadonna
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  4. Bernadette M. Scott
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  5. Ewa Witort
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  6. Geoffrey A. Pietersz
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  7. Ian F. C. McKenzie
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Hogarth, P.M., Hibbs, M.L., Bonadonna, L. et al. The mouse Fc receptor for IgG (Ly-17) : molecular cloning and specificity. Immunogenetics 26, 161–168 (1987). https://doi.org/10.1007/BF00365906

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  • DOI: https://doi.org/10.1007/BF00365906

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