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CT scan appearances in Leigh's disease (subacute necrotizing encephalomyelopathy)

  • Pediatric Neuroradiology
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Summary

Four cases of Leigh's disease (subacute necrotizing encephalomyelopathy), two confirmed at postmortem examination, have been investigated recently by CT scanning. All four showed the same symmetrical areas of low attenuation in the basal ganglia, especially the putamina. These areas corresponded with the typical areas of necrosis seen in this disease. There was also some evidence of atrophic change in the posterior fossa in some cases. This CT scan appearance may be diagnostic in the appropriate clinical context.

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Authors and Affiliations

  1. Department of Neuroradiology and Paediatric Neurology, Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne, UK

    K. Hall & D. Gardner-Medwin

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  1. K. Hall
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  2. D. Gardner-Medwin
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Hall, K., Gardner-Medwin, D. CT scan appearances in Leigh's disease (subacute necrotizing encephalomyelopathy). Neuroradiology 16, 48–50 (1978). https://doi.org/10.1007/BF00395200

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  • DOI: https://doi.org/10.1007/BF00395200

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