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The effect of pre- and post-trial application of nicotine on the 12 problems of the Hebb-Williams-test in the rat

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Abstract

Pre- and post-trial application of 0.15 mg/kg nicotine had, quantitatively and qualitatively, a very similar effect on the Hebb-Williams-test performance of rats. The performance of both treated groups, was for some of the problems of the second half of the test (composed of 12 problems), better than that of the control group. This result suggests a beneficial effect of nicotine on higher integrative functions. The irregularity of the effect from problem to problem of the test was discussed as a consequence of the structural differences between the problems of the test.

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Authors and Affiliations

  1. Department of Industrial Hygiene and Applied Physiology, Swiss Federal Institute of Technology, Zürich, Switzerland

    K. Bättig

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  1. K. Bättig
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Additional information

The experiment was carried through with the help of a grant from the Swiss Association of Cigarette Manufacturers.

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Bättig, K. The effect of pre- and post-trial application of nicotine on the 12 problems of the Hebb-Williams-test in the rat. Psychopharmacologia 18, 68–76 (1970). https://doi.org/10.1007/BF00402385

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  • DOI: https://doi.org/10.1007/BF00402385

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