Abstract
In experiments on mice acute toxicity of morphine did not differ in aggregated and non-aggregated animals. Morphine in doses of 5, 10, 20, 40, 80 mg/kg s.c. did not significantly influence the amphetamine group toxicity in mice.
Preliminary injection of morphine increased the occurance of amphetamine stereotypy and prolonged the duration of stereotypy caused by amphetamine and apomorphine in intact rats, but failed to prolong the duration of the stereotypy in rats tolerant to morphine.
Some differences in the behavioural patterns after injection of amphetamine and apomorphine were observed. The development of tolerance to morphine affected differently the duration of the stereotypies produced by amphetamine and apomorphine.
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Vedernikov, Y.P. The influence of single and chronic morphine administration on some central effects of amphetamine and apomorphine. Psychopharmacologia 17, 283–288 (1970). https://doi.org/10.1007/BF00404233
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DOI: https://doi.org/10.1007/BF00404233