Abstract
Candida albicans contains a cryptic cyanide and antimycin A insensitive respiratory system. This alternate oxidase was found (i) at all growth rates from μ=0.05 to 0.26 in a chemostat culture and (ii) in both mycelial and yeast forms of the organism. Neither chloramphenicol nor cycloheximide prevented the expression of the alternate oxidase. Salicyl-hydroxamic acid was a potent inhibitor of the cyanide insensitive respiration. The respiration of mitochondria grown in the presence of antimycin A was not inhibited by cyanide or antimycin A but was inhibited by salicylhydroxamic acid.
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Abbreviations
- KCN:
-
potassium cyanide
- SHAM:
-
salicyl hydroxamic acid
References
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Shepherd, M.G., Chin, C.M. & Sullivan, P.A. The alternate respiratory pathway of Candida albicans . Arch. Microbiol. 116, 61–67 (1978). https://doi.org/10.1007/BF00408734
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DOI: https://doi.org/10.1007/BF00408734