Summary
Effects of cigarette smoking were examined in eight healthy habitual smokers. Comparisons between effects on catecholamine excretion produced by 2, 4, and 6 cigarettes, smoked within a 2-hr period, showed a progressive increase in adrenaline excretion with number of cigarettes, while noradrenaline excretion was not noticeably affected. Comparisons between smoking and control conditions showed effects on hand steadiness, skin temperature, heart rate, and blood pressure. Dose- and time-response curves indicated that the relatively largest effect was regularly produced by the first cigarette, while the 2nd to 6th cigarette produced progressively smaller changes.
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The experimental work was carried out at the Institute for Alcohol Research, Karolinska Institute, while Dr. M. Waszak, now at the Brain Research Institute, University of California, Los Angeles, joined our research group as a guest worker. The catecholamine analyses were performed by Mrs. I. Linder, and the statistical work by Mr. O. Jonsson. Financial support was obtained from the Swedish Medical Research Council (Project No. 40x-997), and the Swedish Council for Social Science Research.
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Frankenhaeuser, M., Myrsten, A.L., Waszak, M. et al. Dosage and time effects of cigarette smoking. Psychopharmacologia 13, 311–319 (1968). https://doi.org/10.1007/BF00414342
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DOI: https://doi.org/10.1007/BF00414342