Abstract
The cholinergic antisynthesis agent HC-3 was given intraventricularly to young male rats 20–30 days old to deplete brain acetylcholine (ACh). The rate of HC-3 induced depletion of ACh was used as an index of ACh utilization. Total brain ACh was determined following various doses of chlordiazepoxide, pentobarbital, chlorpromazine, methotrimeprazine, imipramine, morphine, d-amphetamine, scopolamine, LSD-25, and phencyclidine given i.p. alone and after intraventricular administration of HC-3. It was found that psychotropic drugs have marked differential effects on the rate of HC-3 induced ACh depletion.
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Supported in part by grant MH-11846, USPHS.
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Domino, E.F., Wilson, A.E. Psychotropic drug influences on brain acetylcholine utilization. Psychopharmacologia 25, 291–298 (1972). https://doi.org/10.1007/BF00421968
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DOI: https://doi.org/10.1007/BF00421968