Abstract
Eight men were studied during graded (47, 77 and 100% of maximal oxygen uptake) and prolonged (76%) exhaustive treadmill running. Plasma catecholamine levels increased progressively with intensity and duration of exercise. Serum concentrations of thyroid-stimulating hormone (TSH) increased with increasing work loads and were 107 (58–243)% (P<0.001) above resting values after maximal work. Thyroxine, triiodothyronine and luteinizing hormone in serum never changed significantly. While a small increase in testosterone concentrations (13 [1–24]%) after maximal exercise probably could be explained by changes in plasma volume, a definite increase (31 [14–56]%) occurred after 40 min of prolonged exercise. During continued exercise testosterone concentrations then gradually declined. Testicular stimulation by the increased catecholamine concentrations possibly contributed to the rise in testosterone concentrations, but no evidence was found for a direct catecholamine induced increase in the activity of the thyroid gland. The exercise induced increase in TSH levels possibly explains the increased thyroid hormone secretion rate, which previously has been found in individuals participating in physical training programs.
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Balsam, A., Leppo, L. E.: Effect of physical training on the mtabolism of thyroid hormones in man. J. appl. Physiol. 38, 212–215 (1975)
Christensen, N. J.: Plasma noradrenaline and adrenaline in patients with thyrotoxicosis and myxedema. Clin. Sci. 45, 163–171 (1973)
Dufau, M. L.: Radioimmunoassay of plasma testosterone. Clin. chim. Acta 37, 109–114 (1972)
Eik-Nes, K. B.: On the relationship between testicular blood flow and secretion of testosterone in anesthetized dogs stimulated with human chorionic gonadotrophin. Canad. J. Physiol. Pharmacol. 42, 671–677 (1964)
Eik-Nes, K. B.: Production and secretion of testicular steroids. Recent Progr. Hormone Res. 27, 517–535 (1971)
Engelman, K., Portnoy, B.: A sensitive double-isotope derivative assay for norepinephrine and epinephrine. Circulat. Res. 26, 53–57 (1970)
Gharib, H., Ryan, R. J., Mayberry, W. E., Hockert, T.: Radioimmunoassay for triiodothyronine (T3). J. clin. Endocr. 33, 509–516 (1971)
Hall, R., Amos, J., Ormston, B. J.: Radioimmunoassay of serum thyrotropin. Brit. med. J. 1, 582–585 (1971)
Hummer, L., Dige-Petersen, H.: The reliability of normal series based on sera from blood donors (Radioimmunoassay of serum thyroxine). Proceedings of the XIII. International Ann. Meeting Soc. Nucl. Med. 1975
Irvine, C. H. G.: Effect of exercise on thyroxine degradation in athletes and non-athletes. J. clin. Endocr. 28, 942–948 (1968)
Melander, A., Nilsson, E., Sundler, F.: Sympathetic activation of thyroid hormone secretion in mice. Endocrinology 90, 194–199 (1972)
Melander, A., Ericson, L. E., Ljunggren, J.-G., Norberg, K.-A., Persson, B., Sundler, F., Tibblin, S., Westgren, U.: Sympathetic innervation of the normal human thyroid. J. clin. Endocr. 39, 713–718 (1974)
Melander, A., Ranklev, E., Sundler, F., Westgren, U.: Beta2-adrenergic stimulation of thyroid hormone secretion. Endocrinology 97, 332–336 (1975)
Odell, W. D., Ross, G. T., Rayford, P. L.: Radioimmunoassay for luteinizing hormone in human plasma or serum. Physiological studies. J. clin. Invest. 46, 248–255 (1967)
Rowell, L. B.: Human cardiovascular adjustments to exercise and thermal stress. Physiol. Rev. 54, 75–159 (1974)
Story, J. A., Griffith, D. R.: Effect of exercise on thyroid hormone secretion rate in aging rats. Horm. Metab. Res. 6, 403–406 (1974)
Sutton, J. R., Coleman, M. J., Casey, J., Lazarus, L.: Androgen responses during physical exercise. Brit. med. J. 1, 520–522 (1973)
Terjung, R. L., Tipton, C. M.: Plasma thyroxine and thyroid-stimulating hormone levels during submaximal exercise in humans. Amer. J. Physiol. 220, 1840–1845 (1971)
Weeke, J.: Circadian variation of the serum thyrotropin level in normal subjects. Scand. J. clin. Lab. Invest. 31, 337–342 (1973)
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Galbo, H., Hummer, L., Petersen, I.B. et al. Thyroid and testicular hormone responses to graded and prolonged exercise in man. Europ. J. Appl. Physiol. 36, 101–106 (1977). https://doi.org/10.1007/BF00423117
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DOI: https://doi.org/10.1007/BF00423117