Abstract
To evaluate to what metabolic event in contracting muscles heart rate (HR) and \(\dot V\) E are related, time courses of femoral and cubital venous [K+], osmolality (OSM), pH, PCO2, PO2, [lactate], and [orthophosphate] ([Pi]) at onset of exercise were studied in athletes (TR) and non-athletes (UT) and compared to time courses of HR and \(\dot V\) E. During ischaemic work with the calf muscles it could be shown that most of these blood constituents were only released from contracting muscles. Thus their time courses reflected the metabolic events in working muscles being not essentially disturbed by non-working parts of the body. Ischaemic work induced, however, substantial increases of HR and \(\dot V\) E. In the course of non-ischaemic bicycle work HR and \(\dot V\) E rose more rapidly in TR than in UT but were lower in TR during the steady state. During non-ischaemic work only the increases of femoral venous [K+] closely mimicked the cardiorespiratory transients in TR as well as in UT. None of the other femoral venous substances showed such a rapid change or such typical variations between TR and UT. Cubital venous [K+] and [Pi] approached femoral venous concentrations only in the second minute after start whereas pH, PCO2, and OSM increased mainly in venous outflow from contracting muscles. PO2 decreased in femoral venous blood of TR and UT, but in cubital venous blood it remained depressed only in UT. It was discussed that the cardiorespiratory adjustment during the initial stages of work was related to K+ release in working muscles and not to O2 consuming or H+ producing processes, nor to release of Pi or increase of OSM.
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References
Achar, M. V. S.: Effect of injection of Locke solution with higher concentration of potassium into femoral artery on blood pressure in cats. J. Physiol. 198, 115–116P (1968)
Ahlborg, G., Hagenfeldt, L., Wahren, J.: Substrate utilization by the inactive leg during one-leg or arm exercise. J. appl. Physiol. 39, 718–723 (1975)
Alam, M., Smirk, F. H.: Observations in man upon a puls accelerating reflex from the voluntary muscles of legs. J. Physiol. (Lond.) 92, 167–177 (1938)
Asmussen, E., Nielsen, M.: Experiments on nervous factors controlling respiration and circulation during exercise employing blocking of the blood flow. Acta physiol. Scand. 60, 103–111 (1964)
Asmussen, E.: Ventilation at transition from rest to exercise. Acta physiol. scand. 89, 68–78 (1973)
Böning, D., Schweigart, U., Tibes, U., Hemmer, B.: Influence of exercise and endurance training on the oxygen dissociation curve of blood under in vivo and in vitro conditions. Europ. J. appl. Physiol. 34, 1–10 (1975)
Condorelli, L., Strano, A., Filocamo, G., Dagianti, A., Condorelli, S., Bartolo, M.: Die für chemische Reize empfindlichen Rezeptoren der peripheren MuskelgefÄ\e und deren Wirkung auf die Atmung. Arch. Kreisl.-Forsch. 33, 72–85 (1960)
Dejours, P.: Control of respiration in muscular exercise. In: Handbook of physiology: Respiration, Vol. 1 (W. O. Fenn, H. Rahn, eds.), pp. 631–648. Washington, D.C.: Amer. Physiol. Soc. 1964
Documenta Geigy: Wissenschaftliche Tabellen, 6. Aufl. Basel: Geigy 1962
von Döbeln, W., åstrand, I., Bergström, A.: An analysis of age and other factors related to maximal oxygen uptake. J. appl. Physiol. 22, 934–938 (1967)
Dubuisson, M.: Untersuchungen über die ReaktionsÄnderung des Muskels im Verlauf der TÄtigkeit. Pflügers Arch. 239, 314–326 (1937)
Farhi, L. E., Rahn, H.: Gas stores of the body and the unsteady state. J. appl. Physiol. 7, 472–484 (1955)
Gebert, G.: Messung der K+- und Na+-AktivitÄt mit Mikroglaselektroden im ExtracellulÄrraum des Kaninchenmuskels bei Muskelarbeit. Pflügers Arch. 331, 204–214 (1972)
Haddy, F. J., Scott, J. B.: Metabolically linked vasoactive chemicals in local regulation of blood flow. Physiol. Rev. 48, 688–707 (1968)
Hanson, J. S., Tabakin, B. S.: Comparison of the circulatory response to upright exercise in 25 “normal” men and 9 distance runners. Brit. Heart J. 27, 211–219 (1963)
Hilton, S. M.: Evidence for inorganic phosphate as the initiator of postcontraction hyperemia in skeletal muscle. Scand. J. clin. Lab. Invest. 29, 135–138 (1969)
Hnik, P., Hudlicka, O., Kucera, J., Payne, R.: Activation of muscle afferents by nonproprioceptive stimuli. Amer. J. Physiol. 217, 1451–1457 (1969)
Hnik, P., Vyskočil, F., KŘiŽ, N., Holas, M.: Work-induced increase of extracellular potassium concentration in muscle measured by ion-specific electrodes. Brain Res. 40, 559–562 (1972)
Hodgson, H. J. F., Matthews, P. B. C.: The ineffectiveness of excitation of the primary endings of the muscle spindle by vibration as a respiratory stimulant in the decerebrate cat. J. Physiol. (Lond.) 194, 555–563 (1968)
Hohorst, H.-J.: l-(+)-Lactat, Bestimmung mit Lactat-Dehydrogenase und NAD. In: Methoden der enzymatischen Analyse, Bd. 2 (H. U. Bergmeyer, Hrsg.), S. 1425–1429. Weinheim (Bergstr.): Verlag Chemie 1970
Hollander, A. P., Bouman, L. N.: Cardiac acceleration in man elicited by a muscle-heart reflex. J. appl. Physiol. 38, 272–278 (1975)
Jensen, J. I., Vejby-Christensen, H., Petersen, E. S.: Ventilation in man at onset of work employing different standardized starting orders. Resp. Physiol. 13, 209–220 (1971)
Keul, J., Doll, E., Keppler, D.: Muskelstoffwechsel. München: Barth 1969
Koller, S.: Statistische Auswertung der Versuchsergebnisse. In: Handbuch der physiol. und pathol. chem. Anal., Bd. 2 (K. Lang, E. Lehnartz, Hrsg.), S. 931–1036. Berlin-Göttingen-Heidelberg: Springer 1955
Lasser, R. F., Schoenfeld, M. R., Allen, D. F., Friedberg, C. K.: Reflex circulatory effects elicited by hypertonic and hypotonic solutions injected into femoral and brachial arteries of dog. Circulat. Res. 8, 913–919 (1960)
Laurell, H., Pernow, B.: Effect of exercise on plasma potassium in man. Acta physiol. scand. 66, 241–242 (1966)
Matell, G.: Time-courses of changes in ventilation and arterial gas tensions in man induced by moderate exercise. Acta physiol. scand. 206 (Suppl.), 1–53 (1963)
McCloskey, D. I., Mitchell, J. H.: Reflex cardiovascular and respiratory responses originating in exercising muscle. J. Physiol. 224, 173–186 (1972)
Ramsay, A. G.: Effects of metabolism and anaesthesia on pulmonary ventilation. J. appl. Physiol. 14, 102–104 (1959)
Rowell, L. B.: Human cardiovascular adjustments to exercise and thermal stress. Physiol. Rev. 54, 75–159 (1974)
Stegemann, J.: Zum Mechanismus der Pulsfrequenzeinstellung durch den Stoffwechsel. I.–IV. Mitteilung. Pflügers Arch. ges. Physiol. 276, 481–524 (1963)
Stegemann, J., Böning, D.: Die Wirkung erhöhter Metabolitkonzentrationen im Muskel auf die Ventilation. Pflügers Arch. 294, 214–222 (1967)
Stegemann, J., Kenner, Th.: A theory on heart rate control by muscular metabolic receptors. Arch. Kreisl.-Forsch. 64, 185–214 (1971)
Stegemann, J., Ulmer, H. V., Böning, D.: Auslösung peripherer neurogener Atmungs- und Kreislaufantriebe durch Erhöhung des CO2-Druckes in grö\eren Muskelgruppen. Pflügers Arch. 293, 155–164 (1967)
Steinhagen, C., Hirche, Hj., Hosselmann, I., Manthey, J., Nestle, H. W., Bovenkamp, U.: Interstitial pH of the isolated working skeletal muscle during acid-base disturbances. Pflügers Arch. 355 (Suppl.), R 122 (1975)
Tibes, U., Hemmer, B.: Relation among venous K+ and orthophosphate concentrations, osmolality, heart rate, and ventilation at the beginning of exercise. Pflügers Arch. 339 (Suppl.), R 27 (1973)
Tibes, U., Hemmer, B.: Peripheral drive on circulatory and ventilatory centers from muscular metabolic receptors. Pflügers Arch. 347, R 47 (1974)
Tibes, U., Hemmer, B., Böning, D., Schweigart, U.: Relationships of femoral venous [K+], [H+], PO2, osmolality, and [orthophosphate] with heart rate, ventilation, and leg blood flow during bicycle exercise in athletes and non-athletes. Europ. J. appl. Physiol. 35, 201–214 (1976)
Tibes, U., Hemmer, B., Schweigart, U., Böning, D., Fotescu, D.: Exercise acidosis as cause of electrolyte changes in femoral venous blood of trained and untrained man. Pflügers Arch. 347, 145–158 (1974)
Tibes, U., Haberkorn, E., Hemmer, B. (with technical assistance of M. Kötter, B. Arndt): Changes of interstitial and venous [K+], [Na+], [Ca++], [Mg++], [Cl−], [PO ≡4 ], osmolality (OSM), [lactate] ([Lac−]), [creatine] ([Cr]), and muscle electrolytes due to muscular contractions. Pflügers Arch. 359 (Suppl.), R 72 (1975)
Weber, E.: Grundri\ der Biologischen Statistik. Stuttgart: Fischer 1967
Wildenthal, K., Mierzwiak, D. S., Skinner, S. N., Jr., Mitchell, J. H.: Potassium-induced cardiovascular and ventilatory reflexes from the dog hindlimb. Amer. J. Physiol. 215, 542–548 (1968)
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Parts of these results were presented elsewhere [36]
Supported by Bundesinstitut für Sportwissenschaft, Köln
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Tibes, U., Hemmer, B. & Böning, D. Heart rate and ventilation in relation to venous [K+], osmolality, pH, PCO2, PO2, [orthophosphate], and [lactate] at transition from rest to exercise in athletes and non-athletes. Europ. J. Appl. Physiol. 36, 127–140 (1977). https://doi.org/10.1007/BF00423120
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DOI: https://doi.org/10.1007/BF00423120