Abstract
The vapor-phase oxidation of 2,5-dimethylpyrazine with oxygen on vanadium-molybdenum oxide catalysts modified with silver oxide gives 5-methyl-2-formylpyrazine and 2,5-diformylpyrazine in 37% and 35% yields, respectively. Pyrazine-2,5-dicarboxylic acid was obtained in 53% yield by the liquid-phase oxidation of 2,5-dimethylpyrazine with oxygen in the presence of a strong base and an interphase catalyst.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 532–537, April, 1990.
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Iovel', I.G., Yansone, I.Y., Gol'dberg, Y.S. et al. Oxidation of 2,5-dimethylpyrazine with oxygen in the vapor phase on oxide catalysts and in the liquid phase in the presence of bases. Chem Heterocycl Compd 26, 456–461 (1990). https://doi.org/10.1007/BF00497221
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DOI: https://doi.org/10.1007/BF00497221