Abstract
Various patterns of mouse pancreatic proteinase activity bands were observed on agarose gel electrophoresis. Prt-1 aand Prt-1 bgenes control the positive (PRT-1A) and negative (PRT-1B) expression of tryptic band V, respectively; Prt-2 aand Prt-2 bcorrespond to chymotryptic bands II (PRT-2A) and III (PRT-2B); Prt-3 aand Prt-3 bcontrol the low (PRT-3A) and high (PRT-3B) tryptic activities of band IV; the Prt-1 and Prt-3 loci are closely linked on the same chromosome; Prt-6 aand Prt-6 bcorrespond to tryptic bands I (PRT-6A) and I′ (PRT-6B). Twenty-four laboratory strains from the United States showed the phenotype PRT-1A, PRT-3A, and PRT-2A. Of laboratory strains established in Europe, 6 showed PRT-1A, PRT-3A, and PRT-2A, and 10 had PRT-1B, PRT-3A, and PRT-2A bands. Most wild mice around the world and their descendants showed the phenotype PRT-1B, PRT-3B, and PRT-2A. Only the phenotype of M. m. brevirostris was PRT-1A, PRT-3A, and PRT-2A, which was the same as most laboratory inbred strains. PRT-2B was observed mainly in Japanese (M. m. molossinus) and Korean (M. m. yamashinai) wild mice. PRT-6B was detected only in Mus spicilegus and Mus caroli, but all other mice including wild populations and laboratory strains showed PRT-6A. New biochemical phenotypes such as PRT-2C and PRT-3C were also found in this study.
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Watanabe, T., Miyashita, N., Moriwaki, K. et al. Evolutionary relationships between laboratory mice and subspecies of Mus musculus based on the genetic study of pancreatic proteinase loci, Prt-1, Prt-2, Prt-3, and Prt-6 . Biochem Genet 25, 239–251 (1987). https://doi.org/10.1007/BF00499317
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DOI: https://doi.org/10.1007/BF00499317