Summary
Chlorphentermine which is known to interfere with lipid metabolism in vivo shows strong interaction with phosphatidylcholine in NMR-binding studies. This complexation is supposed to alter the phospholipid metabolism thus giving rise to intracellular accumulation of lipids. No significant interaction was observed for phentermine.
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Seydel, J.K., Wassermann, O. NMR-Studies on the molecular basis of drug-induced phospholipidosis. Naunyn-Schmiedeberg's Arch. Pharmacol. 279, 207–210 (1973). https://doi.org/10.1007/BF00503985
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DOI: https://doi.org/10.1007/BF00503985