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Synthesis of 5H-pyridazo[4,5-b]indoles by condensation of 2-acylindole-3-carboxylic acids with hydrazine

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

5H-Pyridazo[4,5-b]indol-1-ones were obtained by heating 2-acetylindole-3- or 2-aroylindole-3-carboxylic acids with hydrazine hydrate in ethylene glycol or alcohol. 1-Chloro-5H-pyridazo[4,5-b]indoles are formed by treatment of 5H-pyridazo[4,5-b]indol-1-ones with phosphorus oxychloride.

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Literature cited

  1. N. N. Suvorov, Zh. D. Ovchinnikova, and Yu. N. Sheinker, Zh. Obshch. Khim., 31, 2333 (1961).

    Google Scholar 

  2. R. S. Pandit and S. Seshadri, Indian J. Chem., 12, 943 (1974).

    Google Scholar 

  3. P. Nantka-Namirski and Z. Ozdowska, Acta, Pol. Pharm., 32, 273 (1975).

    Google Scholar 

  4. H. King and E. Stiller, J. Chem. Soc., No. 2, 466 (1937).

    Google Scholar 

  5. N. A. Kogan and M. I. Vlasova, Khim. Geterotsikl. Soedin., No. 12, 1654 (1973).

    Google Scholar 

  6. V. A. Monge, V. Huarte, J. A. Palop, M. T. Martinez, and A. E. Fernandez, An. Quim., 73 (2), 278 (1977); Chem. Abstr., 87, 152107 (1977).

    Google Scholar 

  7. R. Staunton and A. Topham, J. Chem. Soc., No. 6, 1889 (1953).

    Google Scholar 

  8. M. I. Vlasova and N. A. Kogan, Khim. Geterosikl. Soedin., No. 6, 754 (1974).

    Google Scholar 

  9. M. A. Rekhter, V. I. Gorgos, L. M. Zorin, and G. I. Zhungietu, USSR Inventor's Certificate No. 696016; Byull. Izobret., No. 41, 91 (1979).

  10. G. I. Zhungietu, V. I. Gorgos, M. A. Rekhter, and A. I., Korpan', Izv. Akad. Nauk Moldavsk. SSR, Ser. Biol. Khim. Nauk, No. 3, 61 (1980).

    Google Scholar 

  11. G. I. Zhungietu, L. M. Zorin, and M. A., Rekhter, Izv. Akad. Nauk Moldavsk. SSR, Ser. Biol. Khim. Nauk, No. 2, 57 (1981).

    Google Scholar 

  12. A. N. Kost, M. A. Yurovskaya, and Nguyen Minh Thao, Khim. Geterotsikl. Soedin., No. 5, 659 (1975).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Chemistry, Academy of Sciences of the Moldavian SSR, 277028, Kishinev

    G. I. Zhungietu, L. M. Zorin, V. I. Gorgos & M. A. Rekhter

Authors
  1. G. I. Zhungietu
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  2. L. M. Zorin
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  3. V. I. Gorgos
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  4. M. A. Rekhter
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1064–1066, August, 1982.

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Zhungietu, G.I., Zorin, L.M., Gorgos, V.I. et al. Synthesis of 5H-pyridazo[4,5-b]indoles by condensation of 2-acylindole-3-carboxylic acids with hydrazine. Chem Heterocycl Compd 18, 811–813 (1982). https://doi.org/10.1007/BF00506584

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  • DOI: https://doi.org/10.1007/BF00506584

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