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Tierexperimentelle Beobachtungen über das intracerebrale Wachstum menschlicher Tumoren

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Zusammenfassung

Das Wachstumsverhalten zweier in das Gehirn von Goldhamstern implantierter menschlicher Tumoren (H. Ad. Nr. 1 und H. S. Nr. 1) wurde untersucht. Bei allen Tieren konnte ein Tumorwachstum histologisch nachgewiesen werden. Cortisonvorbehandlung der Wirtstiere begünstigte bei H. Ad. Nr. 1 die Tumorausbreitung und führte frühzeitiger zum Tode. Das intracerebrale Tumorwachstum führte jedoch auch unabhängig von der Wirtsvorbehandlung bei allen Tieren zum Tode innerhalb von 4 Wochen nach der Transplantation. Beide Geschwulst-typen wuchsen am besten in den liquorhaltigen Räumen, weniger in der Hirnsubstanz. Die Bevorzugung der Meningen durch beide Tumortypen entspricht der allgemeinen Erfahrung über die cerebrale Metastasierung entdifferenzierte Sarkome und Adenocarcinome.

Summary

The growth behavior of two human tumors (H. Ad. No. 1 and H. S. No. 1) transplanted to the hamster brain has been studied. Tumor growth could be histologically verified in all animals inoculated. Cortisone-conditioning of the host increased tumor expansion and resulted in an earlier and more rapid death rate in the H. Ad. No. 1 group. Regardless of tumor or host-conditioning employed, all animals succumbed to intracerebral tumor growth by the end of the fourth week post transplantation. Both tumor types grew better in the ventricles and subarachnoid space than in the brain tissue itself. The predilection of these two tumor types for the meninges confirms our clinical knowledge on the pattern of cerebral metastasis of dedifferentiated sarcomas and adenocarcinomas.

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Authors and Affiliations

  1. Krebsforschungslabor der Medizinischen Klinik der Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Deutschland

    David M. Goldenberg, Helmut Schmidt & Siegfried Witte

  2. Pathologisches Institut der Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Deutschland

    David M. Goldenberg, Helmut Schmidt & Siegfried Witte

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  1. David M. Goldenberg
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  2. Helmut Schmidt
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  3. Siegfried Witte
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Mit Unterstützung der Deutschen Forschungsgemeinschaft.

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Goldenberg, D.M., Schmidt, H. & Witte, S. Tierexperimentelle Beobachtungen über das intracerebrale Wachstum menschlicher Tumoren. Z Krebs-forsch 69, 316–325 (1967). https://doi.org/10.1007/BF00525144

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  • DOI: https://doi.org/10.1007/BF00525144

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