Abstract
2,2′,4-Trichloro-6′-phenyl-4′,5-dipyrimidinyl, for which nucleophilic substitution with piperdine under various conditions was studied, was obtained from 2,2′,4-trioxo-6′-phenyl-1, 1′,2,2′,3,4-hexahydro-4′,5-dipyrimidinyl. It is shown that there is an appreciable difference in the rates of substitution of the first, second, and third chlorine atoms, and this made it possible to obtain reaction products that contain one, two, and three piperidino groups. The chlorine atom in the 4 position is replaced initially, after which the chlorine atom in the 2 position undergoes substitution. The structures of the compounds were proved by chemical transformations and analysis of the PMR spectra.
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See [1] for communication 69.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 821–826, June, 1979.
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Mikhaleva, M.A., Naumenko, I.I. & Mamaev, V.P. Pyrimidines. 70. Relative reactivities of the chlorine atoms of 2,2′,4-trichloro-4′,5-dipyrimidinyl in its reaction with piperidine. Chem Heterocycl Compd 15, 671–676 (1979). https://doi.org/10.1007/BF00539506
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DOI: https://doi.org/10.1007/BF00539506