Summary
The kinetics of mianserin have been evaluated in eight healthy male volunteers following a single oral dose of 60 mg. Plasma and blood concentrations of mianserin were measured by gas chromatography-mass fragmentography. The peak blood concentration observed was 65 µg/l at 3 h following the dose. Mean kinetic parameters (and range) calculated from the blood concentrations were: (t1/2)abs 1.1 h (0.3–2.8), (t1/2)α 2.5 h (0.9–4.7), (t1/2)β 21 h (14–33), (Vd)β 27.5 l/kg (16.8–46.5) and Cloral 0.98 l/kg/h (0.47–1.75). Blood/plasma concentration ratios ranged from 0.50–0.74.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Burrows GD, Davies B, Hamer A, Vohra J (1979) Effect of mianserin on cardiac conduction. Med J Aust 2: 97–98
Coppen AJ, Gupta R, Montgomery S, Bailey J, Burns B, de Ridder JJ (1976) Mianserin hydrochloride: a novel antidepressant. Br J Psychiatry 129: 342–345
Crome P, Newman B (1977) Poisoning with maprotiline and mianserin. Br Med J 2: 260
Itil TM, Polvan N, Hsu W (1972) Clinical and EEG effects of GB94, a tetracyclic antidepressant. Curr Ther Res 14: 395–413
Jansen H (1978) Contribution to workshop on the clinical pharmacology and efficacy of mianserin. Br J Clin Pharmacol 5: 91S-99S
Maguire KP, Norman TR, Burrows GD, Scoggins BA (1981) Simultaneous measurement of dothiepin and its major metabolites in plasma and whole blood by gas chromatography-mass fragmentography. J Chromatogr 222: 399–408
Murphy JE (1975) A comparative clinical trial of Org GB94 and imipramine in the treatment of depression in general practice. J Int Med Res 3: 251–260
Murphy JE, Donald JF, Molla AL (1976) Mianserin in the treatment of depression in general practice. Practitioner 217: 135–138
Peet M, Behagel H (1978) Mianserin: A decade of scientific development. Br J Clin Pharmacol 5: 5S-9S
Pichot P, Dreyfus JF, Pull C (1978) A double-blind multicentre trial comparing mianserin with imipramine. Br J Clin Pharmacol 5: 87S-90S
de Ridder JJ, Koppens PCJM, van Hal JM (1977) Mass fragmentographic assay of nanogram amounts of the antidepressant drug mianserin hydrochloride (Org GB94) in human plasma. J Chromatogr 143: 289–297
Smith AHW, Naylor GS, Moody JP (1978) Placebo-controlled double-blind trial of mianserin hyrochloride. Br J Clin Pharmacol 5: 67S-70S
Wagner JG (1975) Fundamentals of clinical pharmacokinetics. Drug Intelligence Publications, Hamilton, IL, USA
Wheatley D (1975) Controlled trial of a new antidepressant (Org GB94) of novel chemical formulation. Curr Ther Res 18: 849–854
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Maguire, K.P., Norman, T.R., Burrows, G.D. et al. A pharmacokinetic study of mianserin. Eur J Clin Pharmacol 21, 517–520 (1982). https://doi.org/10.1007/BF00542048
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00542048