Summary
A double-blind, cross-over study in 16 patients with essential hypertension was carried out, to evaluate any possible interference by indomethacin, a known prostaglandin-synthetase inhibitor, with the antihypertensive effect of oxprenolol, a non-selective beta-adrenoceptor blocking agent. Both indomethacin and oxprenolol, as well as the two drugs combined, inhibited plasma renin activity; no change was found in urinary sodium excretion or body weight. Oxprenolol alone caused a highly significant decrease in the systolic (−10.4 mmHg,p<0.001), diastolic (−7.4 mmHg,p<0.001) and mean (−7.7 mmHg,p<0.01) blood pressures, whereas indomethacin did not influence blood pressure. When the two drugs were given in combination, blood pressure decreased (systolic: −5.9 mmHg; diastolic: −4.0 mmHg; mean: −4.6 mmHg), but the changes induced in blood pressure were reduced by about 50% when compared with those in the oxprenolol alone period. The data show that indomethacin seems to interfere with the antihypertensive effect of oxprenolol, by an action which may be due to the inhibition of prostaglandin synthesis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Mc Giff JC, Vane JR (1975) Prostaglandins and regulation of blood pressure. Kidney Int 8: S 262–270
Anderson RJ, Berl T, Mc Donald K, Schier RW (1978) Prostaglandin effects on blood pressure, renal blood flow, sodium and water excretion. Kidney Int 10: 205–215
Flower R, Gryglewski R, Herbaczynska-Cedro K, Vane JR (1972) Effects of antiinflammatory drugs on prostaglandin biosynthesis. Nature (New Biol) 238: 104–106
Durâo U, Rico GT (1977) Modification by indomethacin of the blood pressure lowering effect of pindolol and propranolol in conscious rabbits. Eur J Pharmacol 43: 377–381
Haeusler G, Gerold M (1979) Increased levels of prostaglandin-like material in the canine blood during arterial hypotension produced by hydralazine, dihydralazine and minoxidil. Naunyn Schmiedebergs Arch Pharmacol 310: 155–167
Rubin P, Jackson G, Blaschke T (1980) Studies on the clinical pharmacology of prazosin. II: The influence of indomethacin and of propranolol on the action and disposition of prazosin. Br J Clin Pharmacol 10: 33–39
Salvetti A, Sassano P, Pedrinelli R, Arzilli F (1980) The influence of indomethacin on the pharmacological actions of captopril in renovascular patients. Drugs Exp Clin Res 6: 541–553
Abe K, Itoh T, Imai Y, Sato M, Haruyama T, Sakurai Y, Goto T, Otsuka Y, Yoshinaga K (1980) Implication of endogenous prostaglandin system in the antihypertensive effect of captopril SQ 14225 in low renin hypertension. Jpn Circ J 44: 422–425
Watkins J, Abbott EC, Hensby CN, Webster J, Dollery CT (1980) Attenuation of hypotensive effect of propranolol and thiazide diuretics by indomethacin. Br Med J 281: 702–705
Lopez-Ovejero JA, Weber MA, Drayer JI, Sealey JE, Laragh JH (1978) Effects of indomethacin alone and during diuretics or beta-adrenoreceptors blockade therapy on blood pressure and the renin system in essential hypertension. Clin Sci Mol Med 55: 203s-205s
Webster J, Dollery CT, Hensby CN, Friedman LA (1980) Antihypertensive action of bendrofluemethiazide: increased prostacyclin production? Clin Pharmacol Ther 28: 751–758
Brunner H, Hedwall PR, Maier R, Meier M (1970) Pharmacological aspects of oxprenolol. Postgrad Med J 46 (Suppl. Nov): 5–14
Malvano R, Zucchelli GC, Rosa U, Salvetti A (1972) Measurement of plasma renin activity by Angiotensin I radioimmunoassay (I): an assessment of some methodological aspects. J Nucl Biol Med 16: 24–31
Malvano R, Orlandini S, Cozzani P, Duranti P, Simonini N, Salvetti A (1976) Methodological simplifications in radioimmunoassay of urinary aldosterone. Clin Chim Acta 66: 331–334
Snedecor GW, Cochran WG (1967) Statistical methods. IV Ed., Iowa State University Press: Ames, IA
Pedrinelli R, Arzilli F, Cavasinni L, Poli L, Sassano P, Salvetti A (1980) The effect of indomethacin on plasma renin activity and urinary aldosterone of patients with essential hypertension. J Endocrinol Invest 1: 315–320
Salvetti A, Pedrinelli R, Magagna A, Arzilli F, Sassano P (1980) The effect of indomethacin on renin and blood pressure of renovascular patients. International Symposium on “Prostaglandins and the kidney”, Stuttgart, Germany, Abstract n. 59
Brater DC (1979) Effect of indomethacin on salt and water homeostasis. Clin Pharmacol Ther 25: 322–330
Frölich JC, Hollifield JW, Michelakis AM, Vesper BS, Shand DG, Wilson JP, Seyberth HJ, Frölich WH, Oates JA (1979) Reduction of plasma renin activity by inhibition of the fatty acid cyclooxygenase in human subjects; independence of sodium retention. Circ Res 44: 781–787
Horton EW (1973) Prostaglandins at adrenergic nerve endings. Br Med Bull 29: 148–151
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Salvetti, A., Arzilli, F., Pedrinelli, R. et al. Interaction between oxprenolol and indomethacin on blood pressure in essential hypertensive patients. Eur J Clin Pharmacol 22, 197–201 (1982). https://doi.org/10.1007/BF00545214
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00545214