Summary
In this study the well-established interaction between cimetidine and theophylline has been demonstrated using only a single dose of cimetidine. Eleven healthy subjects were given a 30 min infusion of theophylline on two separate occasions and plasma levels were monitored at frequent intervals. During one of the studies, a single 400 mg oral dose of cimetidine was given after collection of the 3 h sample. After normalisation of the control and test curves, a deflection was apparent in the test theophylline elimination curve in 9 out of 11 subjects. This method may provide a rapid screening method to detect such interactions.
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Ghabrial, H., Harman, P.J., Desmond, P.V. et al. Use of single doses and rapid sampling to detect interactions with cimetidine. Eur J Clin Pharmacol 27, 603–606 (1984). https://doi.org/10.1007/BF00556899
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DOI: https://doi.org/10.1007/BF00556899