Summary
It has been shown that BOC derivatives of amino acids can be obtained by the tert-butoxycarbonylation of amino-acid salts with di-tert-butylpyrocarbonate in aqueous organic solutions.
Similar content being viewed by others
Literature cited
J. Stewart and D. Young, Solid-Phase Peptide Synthesis, W. H. Freeman, San Francisco (1969).
L. Carpino, K. Parameswaran, R. Kirkley, J. Spiewak, and E. Schmitz, J. Org. Chem.,35, 3293 (1970).
L. Carpino, J. Amer. Chem. Soc.,82, 2725 (1960).
V. F. Pozdnev, Khim. Prirodn. Soedin., 384 (1971).
V. F. Pozdnev, Zh. Organ. Khim.,7, 1079 (1971).
E. Schnabel, Ann. Chem.,702, 188 (1967).
E. Schnabel, H. Herzog, P. Hoffmann, E. Klauke, and J. Ugi. Ann. Chem.,716, 175 (1968).
R. Schwizer and W. Rittel, Helv. Chim. Acta,44, 159 (1961).
G. W. Anderson and A. McGregor, J. Amer. Chem. Soc.,79, 6180 (1957).
Additional information
Institute of Biological and Medicinal Chemistry, Academy of Sciences of the USSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 764–767, November–December, 1974.
Rights and permissions
About this article
Cite this article
Pozdnev, V.F. Use of di-tert-butyl pyrocarbonate to obtain N-tert-butoxycarbonyl derivatives of amino acids. Chem Nat Compd 10, 782–784 (1974). https://doi.org/10.1007/BF00563997
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00563997