Abstract
The condensation of 2-amino-3-methylquinazolin-4-one and its 6-nitro derivative with dialkyl-, arylalkyl-, and heterylformamides has given the corresponding formamidines of the quinazolinone series. The details of the compounds synthesized are as follows X, R, R′, yield (%), mp (°C, ethanol), Rf (chloroform-methanol (20:1) Al2O3): empirical formula: H, CH3, CH3, 77, 238–240, 0.49, C12H14ON4; H, C2H5, C2H5, 65, 208–210, 0.96, C14H18ON4; H, CH3, C6H5, 84, 162–164, 0.54, C17H16ON4; H, (CH2)2O(CH2)2, 60, 196–197, 0.43, C14H16O2N4; H, (CH2)5, 6.6, 196–198, 0.4, C15H18·ON4; NO2, CH3, CH3, 64. 194–196, 0.83, C12H13O3N5; NO2, C2H5, C2H5, 37, 142–144, 0.8, C14H17O3N5; NO2; CH3, C6H5, 38, 298, 0.88, C17H15O3N5; NO2, (CH2)2O(CH2)2, 60, 148–150, 0.7, C14H15O4N5.
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Additional information
Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 680–684, September–October, 1980.
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Yun, L.M., Makhmudov, S.A., Shakhidoyatov, K.M. et al. Synthesis of formamidines from 2-amino-3-methylquinazolin-4-one and its 6-nitro derivative. Chem Nat Compd 16, 495–498 (1980). https://doi.org/10.1007/BF00571048
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DOI: https://doi.org/10.1007/BF00571048