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Oligonucleotides and nucleotidopeptides. XLII. Efficacy of the intramolecular influence of the carboxy groups of amino acids in nucleotidyl-(P → N)-amino acids (peptides) as a function of their positions

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Abstract

It has been established that remote carboxy groups in nucleotidyl-(5′ → N)-β-alanine and -alanylalanine do not affect the mechanism of the cleavage of the phosphoramide center. The situation is different in the case of nucleotidyl-(5′ → Nɛ)-lysine. It has been shown that in the 3′-phenylalanine derivative of dTMP, the influence of the α-carboxy group of the amino acid is only half as great as in the 5′-analog. The α-carboxy groups of the amino acids in oligonucleotidyl-(Pin → N)-amino acids also weaken the mechanism of the cleavage of the phosphoramide centers.

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Authors
  1. B. A. Yuodka
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  2. L. E. Lioranchaite
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  3. V. R. Baltenas
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Additional information

V. Kapsukas Vilnius State University. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 740–746, November–December, 1982.

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Yuodka, B.A., Lioranchaite, L.E. & Baltenas, V.R. Oligonucleotides and nucleotidopeptides. XLII. Efficacy of the intramolecular influence of the carboxy groups of amino acids in nucleotidyl-(P → N)-amino acids (peptides) as a function of their positions. Chem Nat Compd 18, 703–708 (1982). https://doi.org/10.1007/BF00579428

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  • DOI: https://doi.org/10.1007/BF00579428

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