Abstract
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1.
The dynamic analysis of the control exerted by neck and macular vestibular receptors on the cerebellar cortex has been investigated in precollicular decerebrate cats submitted to sinusoidal rotation along the longitudinal axis of the animal at the frequency of 0.026 Hz and at peak amplitudes up to 10° for the neck input and 15° for the macular input.
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2.
Purkinje (P) cells located in the vermal cortex of the cerebellar anterior lobe, particularly in the longitudinal parasagittal zone which projects to the ipsilateral lateral vestibular nucleus (LVN), showed a sinusoidal modulation of the firing rate in response to sinusoidal stimulation of the neck receptors or the vestibular receptors, the phase of the responses being in most units related to the extreme neck or head position. Mossy fiber (MF) and/or climbing fiber (CF) responses of the same or different P-cells to the two inputs were observed.
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3.
The sensitivity of the MF-response of the P-cells to the neck input, elicited by sinusoidal rotation of the neck and expressed in per cent of the average firing rate per degree of neck rotation, corresponded on the average to 2.71±1.67, S. D. This value was significantly higher than that of the MF-response of the P-cells to the macular input elicited by sinusoidal tilt along the longitudinal axis of the whole animal, which corresponded to 1.71±1.01, S.D.
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4.
Most of the MF-responses of the P-cells to the neck input were characterized by an excitation during side-down rotation of the neck and by an inhibition during side-up rotation, whereas most of the MF-responses of the P-cells to the macular input showed just the opposite behavior, being inhibited by side-down tilt of the animal and excited by side-up tilt.
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5.
Units which received a convergent input from both neck and macular receptors and showed an antagonistic pattern of response to the two inputs were tested during rotation of the head alone, in order to excite simultaneously the two kinds of receptors. Due to the higher sensitivity of the neck over the macular response, the magnitude of the combined response tended to be similar to the difference between the individual ones. Moreover, the phase of the resulting response was always modified with respect to that of the response to the neck input alone, and became in some instances related to velocity of neck rotation rather than to neck position.
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6.
These findings indicate that opposite responses to neck and macular inputs occur at corticocerebellar level. However, a final integration of the two inputs, leading to suppression of the conflicting responses, may occur either at medullary (LVN) or at spinal cord level.
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References
Ajala, G. F., Poppele, R. E.: Some problems in the central actions of vestibular inputs. In: Neurophysiological basis of normal and abnormal motor activities (M. D. Yahr and D. P. Purpura, eds.), pp. 141–154. New York: Raven Press 1967
Berthoz, A., Llinás, R.: Afferent neck projection to the cat cerebellar cortex. Exp. Brain Res.20, 385–401 (1974)
Brodal, A.: Anatomy of vestibular nuclei and their connections. In: Handbook of sensory physiology, Vol. VI/1. Vestibular system. Part 1. Basic mechanisms (H. H. Kornhuber, ed.), pp. 239–352. Berlin, Heidelberg, New York: Springer 1974
Brodal, A., Pompeiano, O., Walberg, F.: The vestibular nuclei and their connections. Anatomy and functional correlations. William Ramsay Henderson Trust Lecture, pp. VIII-193. Edinburgh, London: Oliver and Boyd, 1962
Corvaja, N., Grofová, I., Pompeiano, O., Walberg, F.: The lateral reticular nucleus in the cat. II. Effects of lateral reticular lesions on posture and reflex movements. Neuroscience2, 929–943 (1977)
Corvaja, N., Pompeiano, O.: Identification of cerebellar corticovestibular neurons retrogradely labeled with horseradish peroxidase. Neuroscience4, 507–515 (1979)
Coulter, J. D., Mergner, T., Pompeiano, O.: Effects of static tilt on cervical spinoreticular tract neurons. J. Neurophysiol.39, 45–62 (1976)
Darian-Smith, I., Phillips, G., Ryan, R. D.: Functional organization in the trigeminal main sensory and rostral spinal nuclei of the cat. J. Physiol. (Lond.)168, 129–146 (1963)
Denoth, F., Magherini, P. C., Pompeiano, O., Stanoiević, M.: Response of Purkinje neurons to sinusoidal stimulation of neck receptors. J. Neurophysiol. (in press, 1979)
Eccles, J. C., Ito, M., Szentágothai, J.: The cerebellum as a neuronal machine, pp. 335. Berlin, Heidelberg, New York: Springer 1967
Ehrhardt, K. J., Wagner, A.: Labyrinthine and neck reflexes recorded from spinal single motoneurons in the cat. Brain Res.19, 87–104 (1970)
Erway, L., Ghelarducci, B., Pompeiano, O., Stanojević, M.: Risposta dei neuroni cerebellari di Purkinje e fastigiali al tilt sinusoidale. Atti Congr. Soc. ital. Biol. sper., Soc. ital. Fisiol., Soc. ital. Nutr. um., Siena, n. 60 (1977)
Erway, L., Ghelarducci, B., Pompeiano, O., Stanoiević, M.: Response of Purkinje and fastigial nucleus neurons to sinusoidal tilt. Midwinter Research Meeting, Ass. Res. Otolaryng. St. Petersburg Beach, Florida, Jan. 30–Febr. 1. 1978
Ghelarducci, B., Pompeiano, O., Spyer, K. M.: Activity of precerebellar reticular neurons as a function of head position. Arch. Ital. Biol.112, 98–125 (1974)
Gordon, G., Jukes, M. G. M.: Dual organization of the exteroceptive components of the cat's gracile nucleus. J. Physiol. (Lond.)173, 263–290 (1964)
Hoshino, K., Pompeiano, O.: Responses of lateral vestibular neurons to stimulation of contralateral macular labyrinthine receptors. Arch. Ital. Biol.115, 237–261 (1977)
Iosif, G., Pompeiano, O., Strata, P., Thoden, U.: The effects of stimulation of spindle receptors and Golgi tendon organs on the cerebellar anterior lobe. II. Response of Purkinje cells to sinusoidal stretch or contraction of hindlimb extensor muscles. Arch. Ital. Biol.110, 502–542 (1972)
Ito, M.: Neurophysiological aspects of the cerebellar motor control system. Int. J. Neurol.7, 162–176 (1970)
Ito, M.: Neural design of the cerebellar motor control system. Brain Res.40, 81–84 (1972)
Kim, J. H., Partridge, L. D.: Observations on types of response to combination of neck, vestibular and muscle stretch signals. J. Neurophysiol.32, 239–250 (1969)
Lindsay, K. W., Rosenberg, J. R.: The effect of cerebellectomy on tonic labyrinth reflexes in the forelimb of the decerebrate cat. J. Physiol. (Lond.)273, 76–77P (1977)
Lindsay, K. W., Roberts, T. D. M., Rosenberg, J. R.: Asymmetric tonic labyrinth reflexes and their interaction with neck reflexes in the decerebrate cat. J. Physiol. (Lond.)261, 583–601 (1976)
Lund, S., Pompeiano, O.: Monosynaptic excitation of alpha-motoneurons from supraspinal structures in the cat. Acta Physiol. Scand.73, 1–21 (1968)
Magherini, P. C., Pompeiano, O., Stanoiević, M.: Convergence of macular and neck afferent inputs on Purkinje cells of the cerebellar anterior lobe. Neurosci. Lett. Suppl.1, S355 (1978)
Magnus, R.: Körperstellung, pp. XIII-740. Berlin: Springer 1924
Magnus, R., de Kleijn, A.: Die Abhängigkeit des Tonus der Extremitätenmuskeln von der Kopfstellung. Pflügers Arch.145, 455–548 (1912)
Manzoni, D., Pompeiano, O., Stampacchia, G.: Tonic cervical influences on posture and reflex movements. Arch. Ital. Biol.117, 81–110 (1979)
McCouch, G. P., Deering, I. D., Ling, T. H.: Location of receptors for tonic neck reflexes. J. Neurophysiol.14, 191–195 (1951)
Peterson, B. W.: Distribution of neural responses to tilting within vestibular nuclei of the cat. J. Neurophysiol.33, 750–767 (1970)
Pompeiano, O.: Macular input to neurons of the spinoreticulocerebellar pathway. Brain Res.95, 351–368 (1975)
Pompeiano, O.: Cerebellar control of the vestibulospinal reflex arc. In: IFAC-Symposium of central mechanisms in bio- and ecosystems. Vol. 3: Visual and vestibular control of movements, pp. 130–142. Leipzig 1977
Pompeiano, O., Brodal, A.: The origin of vestibulospinal fibers in the cat. An experimental-anatomical study with comments on the descending medial longitudinal fasciculus. Arch. Ital. Biol.95, 166–195 (1957)
Pompeiano, O., Hoshino, K.: Responses to static tilts of lateral reticular neurons mediated by contralateral labyrinthine receptors. Arch. Ital. Biol.115, 211–236 (1977)
Precht, W., Volkind, R., Blanks, R. H. I.: Functional organization of the vestibular input to the anterior and posterior cerebellar vermis of cat. Exp. Brain Res.27, 143–160 (1977)
Roberts, T. D. M.: Reflex balance. Nature244, 156–158 (1973)
Spyer, K. M., Ghelarducci, B., Pompeiano, O.: Gravity responses of neurons in main reticular formation. J. Neurophysiol.37, 705–721 (1974)
Wenzel, D., Thoden, U.: Modulation of hindlimb reflexes by tonic neck positions in cats. Pflügers Arch.370, 277–282 (1977)
Wenzel, D., Thoden, U., Frank, A.: Forelimb reflexes modulated by tonic neck position in cats. Pflügers Arch.374, 107–113 (1978)
Wilson, V. J., Peterson, B. W.: Peripheral and central substrates of vestibulospinal reflexes. Physiol. Rev.58, 80–105 (1978)
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Denoth, F., Magherini, P.C., Pompeiano, O. et al. Responses of purkinje cells of the cerebellar vermis to neck and macular vestibular inputs. Pflugers Arch. 381, 87–98 (1979). https://doi.org/10.1007/BF00582338
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DOI: https://doi.org/10.1007/BF00582338