Summary
Perfusion experiments were carried out in the proximal jejunum and in the distal ileum of conscious rats, using a newly devised technique. The stimulation effect of actively transported hexoses on the sodium, potassium and fluid absorption is demonstrated.
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1.
There are quantitative differences concerning the effect of 3-O-methyl-d-glucose andd-glucose on the sodium and water absorption.
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2.
The stimulation by glucose can be seen only when the glucose concentration in the luminal fluid is greater than 10 mM.
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3.
The ratio of 3-O-methyl-d-glucose- to sodium-transfer-rate is >1, while it is exactly 1 in the experiments involvingd-glucose.
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4.
The sodium-water equivalent is isotonic under all experimental conditions.
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5.
In the presence of actively transported hexoses the secretion of potassium into an initially K+-free perfusate is significantly diminished.
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6.
The transport of potassium depends on the net fluid movement.
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7.
The stimulation of glucose and 3-O-methyl-d-glucose can only be demonstrated in the jejunum of rat whereas no effect is seen in the distal ileum and colon.
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8.
These results suggest that “solvent drag” isone factor which under the above mentioned experimental conditions affects the enhanced electrolyte and water absorption in the jejunum of the rat.
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Dennhardt, R., Haberich, F.J. Die Wirkung aktiv transportierter Zucker auf den Natrium-, Kalium- und Volumentransport am Jejunum und Ileum der Ratte. Pflugers Arch. 345, 221–236 (1973). https://doi.org/10.1007/BF00586336
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DOI: https://doi.org/10.1007/BF00586336