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The effect of chronic ethanol administration on high affinity3H-nicotinic binding in rat brain

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Summary

The effect of chronic ethanol administration on high affinity3H-nicotinic binding in rat brain was investigated. Chronic ethanol administration for 5 months incuded a significant decrease in the number of specific nicotinic binding sites in the hippocampus, whereas a significant increase in the number of nicotinic binding sites both in the hypothalamus and in the thalamus was found. Similar effects were observed both after administration of a lower concentration (8% W/V) ethanol and a higher concentration (16% W/V) indicating that the duration of the administration seems to be of importance for the biochemical changes observed.

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References

  • Davis KL, Yamamura HI (1978) Cholinergic underactivity in human memory disorders. Life Sci 23: 1729–1733

    Google Scholar 

  • Hunt WA, Dalton TK (1976) Regional brain acetylcholine levels in rats acutely treated with ethanol or rendered ethanol dependent. Brain Res 109: 628–631

    Google Scholar 

  • Hunt MA, Majchrowicz E, Dalton TK (1979) Alteration in high-affinity choline uptake in brain after acute and chronic ethanol treatment. J Pharmacol Exp Ther 210: 259–263

    Google Scholar 

  • Liljequist S, Ahlenius S, Engel J (1977) The effect of chronic ethanol treatment on behaviour and central monoamines in the rat. Naunyn-Schmiedeberg's Arch Pharmacol 300: 205–216

    Google Scholar 

  • Pelham RW, Marquis JK, Kugelmann K, Munsat TL (1980) Prolonged ethanol consumption produces persistent alteration of cholinergic function in rat brain. Alcoholism: Clin and Exp Res 4: 282–287

    Google Scholar 

  • Pohorecky LA, Makowski E, Newman B, Rassi E (1979) Cholinergic mediation of motor effects of ethanol in rats. Eur J Pharmacol 55: 67–72

    Google Scholar 

  • Romano C, Goldstein A (1980) Stereospecific nicotine receptors on rat brain membranes. Science 210: 647–650

    Google Scholar 

  • Tabakoff B, Munoz-Marcus M, Fields JZ (1979) Chronic ethanol feeding produces an increase in muscarinic cholinergic receptors in mouse brain. Life Sci 25: 2173–2180

    Google Scholar 

  • Walker DW, Barnes DE, Zornetzer SF, Hunter BE, Kubanis P (1980) Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats. Science 209: 711–713

    Google Scholar 

  • Yoshida K, Imura H (1979) Nicotinic cholinergic receptors in brain synaptosomes. Brain Res 172: 453–459

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, University of Gothenburg, P.O. Box 33031, S-400 33, Göteborg, Sweden

    Kazuhide Yoshida, Jörgen Engel & Sture Liljequist

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  1. Kazuhide Yoshida
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  2. Jörgen Engel
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  3. Sture Liljequist
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Yoshida, K., Engel, J. & Liljequist, S. The effect of chronic ethanol administration on high affinity3H-nicotinic binding in rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 321, 74–76 (1982). https://doi.org/10.1007/BF00586353

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  • DOI: https://doi.org/10.1007/BF00586353

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