Abstract
Intraspinal microstimulation was used to test the excitability of single cutaneous (sural) A- and C-fibers at their central terminals in the cat. Systemic morphine (1.0–2.6 mg/kg) increased the antidromic threshold to 110% (mean value) of control in C-fibers. In some of the C-fibers this effect was reversed by naloxone. A-fibers were not consistently affected by mophine.
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Preliminary reports were given at the NIMH-conference on “Endorphins in mental health research”, held in San Juan, Puerto Rico (1977), and at the joint meeting of the British and German Physiological Societies, Cambridge/England (July 1978)
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Carstens, E., Tulloch, I., Zieglgänsberger, W. et al. Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers. Pflugers Arch. 379, 143–147 (1979). https://doi.org/10.1007/BF00586940
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DOI: https://doi.org/10.1007/BF00586940