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Non-occurrence of a natriuretic factor in circulating blood of rats after expansion of the extracellular or the intravascular space

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Summary

Evidence for the occurrence of a natriuretic factor in rats, in which diuretic and natriuretic responses had been induced, either by expanding the extracellular or the blood volume, was sought in isovolemic cross-circulation experiments, in which a sizable fraction of the cardiac output was exchanged per unit time. In 8 experiments, in which the extracellular space of the donor animal was expanded by infusing isotonic saline, no diuretic or natriuretic response was observed in the recipients, though the recipients' blood underwent the same hemodilution as that of the donors. In six experiments in which the intravascular volume of the donor animal was considerably expanded by injecting heparinized blood obtained from other rats, cross-circulation did not induce any natriuresis or diuresis in the recipients. A natriuretic response was observed in one such cross-circulation experiment and was presumably due to an experimental error. The data do not lend any support to the hypothesis of a circulating natriuretic factor in isotonic saline diuresis or in diuresis after blood volume expansion.

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  1. J. Ph. Bonjour

    Present address: Physiopathologisches Institut der Universität, Bern, Switzerland

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  1. Institut de Pharmacologie de l'Université de Lausanne, Switzerland

    J. Ph. Bonjour & G. Peters

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Supported by Fonds National Suisse de la Recherche Scientifique: grants No. 4190 and 5315.3.

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Bonjour, J.P., Peters, G. Non-occurrence of a natriuretic factor in circulating blood of rats after expansion of the extracellular or the intravascular space. Pflugers Arch. 318, 21–34 (1970). https://doi.org/10.1007/BF00588540

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