Summary
The action potential duration, tension, time to peak tension, mean rate of tension development, and ATP content of guinea pig ventricular muscle declined during 60 min of anoxic incubation. The decline in tension was closecorrelated with the decline in mean rate of tension development, whereas time to peak tension decreased in an S-shaped relationship with action potential duration decrease. When muscles were incubated under anoxic conditions for 5, 30, or 60 min then under control conditions for 30 min, the action potential duration and time to peak tension returned to control level; tension, mean rate of development, and ATP content did not recover to control level when the period of anoxia exceeded 5 min. During the first 10 min of re-oxygenation a transient overshoot of control value was noted in action potential duration and time to peak tension. The transient increase in time to peak tension was accompanied by a transient increase in tension. It was not dependent on the occurrence, or degree, of overshoot in action potential duration. Transient changes did not occur in mean rate of tension development.
It has been concluded that the anoxia-induced decrease in tension is due to a decrease in the rate of tension development as a result of a decreased ATP suppl. Time to peak tension seems related to action potential duration and both are independent oftotal muscle ATP content.
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Supported by grants from the Canadian and Nova Scotia Heart Foundations and the Medical Research Council of Canada.
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Mcdonald, T.F., MacLeod, D.P. Anoxia-recovery cycle in ventricular muscle: Action potential duration, contractility and ATP content. Pflugers Arch. 325, 305–322 (1971). https://doi.org/10.1007/BF00592172
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DOI: https://doi.org/10.1007/BF00592172