Abstract
The effect of a water-soluble β-cyclodextrin polymer on the lipophilicity and adsorption strength of 17 substituteds-triazine derivatives was studied by thin-layer chromatography. Beta-cyclodextrin polymer dissolved in the mobile phase modifies the chromatographic behaviour ofs-triazine derivatives and, consequently, higherR f and lowerR M values were observed. LiCl exerts an opposite influence, it decreases theR f and increases theR M values. The β-cyclodextrin polymer enhances the mobility of thes-triazine derivatives on silica gel and reduces their lipophilicity, thus promoting their penetration through the hydrophilic membranes of the target organism. The presence of LiCl decreases the stability of inclusion complexes. The first and second substituents on thes-triazine ring result in an increase of the inclusion complex stability but — due to steric hindrances — the third substituent decreases it.
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Cserháti, T., Bordás, B., Fenyvesi, É. et al. Chromatographic properties ofs-triazines in the presence of soluble β-cyclodextrin polymer. Journal of Inclusion Phenomena 1, 53–59 (1983). https://doi.org/10.1007/BF00658015
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DOI: https://doi.org/10.1007/BF00658015