Summary
By electron microscopy cerebral cortex taken post portem from a case of senile dementia was examined especially with regard to “Drüsige Entartung der Hirnarterien” (Scholz, 1938).
The basement mebrane of capillaries was irregularly enlarged, and had produced numerous amyloid fibrils and collagen. In the cytoplasm of the endothelial cells amyloid fibrils were also observed. Amyloid fibrils of the core of senile plaques would seem to be produced by the basement membrane of the blood vessels.
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Miyakawa, T., Sumiyoshi, S., Murayama, E. et al. Ultrastructure of capillary plaque-like degeneration in senile dementia. Acta Neuropathol 29, 229–236 (1974). https://doi.org/10.1007/BF00685258
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DOI: https://doi.org/10.1007/BF00685258