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References
Li FP, Fraumeni JF, Jr: Rhabdomyosarcoma in children: epidemiology study and identification of a familial cancer syndrome. JNCI 43: 1365–1373, 1969
Li FP, Fraumeni JF, Jr, Mulvihill JJ, Blattner WA, Dreyfus MG, Tucker MA, Miller RW: A cancer family syndrome in twenty-four kindreds. Cancer Res 48: 5358–5362, 1988
Williams WR, Strong LC: Genetic epidemiology of soft tissue sarcomas in children.In: Karger S, Basel (eds) Familial Cancer, Weber Muller, 1985, 151-153
Lustbader ED, Williams WR, Bondy ML, Strom S, Strong LC: Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients. Am J Hum Genet 51: 344–356, 1992
Bischoff F, Yim SO, Pathak S, Grant G, Siciliano MJ, Giovanella BC, Strong LC, Tainsky MA: Spontaneous immortalization of normal fibroblasts from patients with Li-Fraumeni cancer syndrome. Cancer Res 50: 7979–7984, 1990
Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD: Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70: 923–935, 1992
Rogan EM, Bryan Hakku B, Maclean K, Chang ACM, Moy EL, TM, Enlezou A, Warneford, Dalla-Pozza L, SG, Reddel RR: Changes in p53 status and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts, manuscript submitted toCancer Research
Shay JW, Tomlinson G, Platyazek MA, Gollahon LS: Spontaneousin vitro immortalization of breast epithelial cells from a Li-Fraumeni patient. Mol Cell Biol. In press
Smith JR, Ning Y & Pereira-Smith OM: Why are transformed cells immortal? Is the process reversible? Am J Clin Nutr 55: 1215S-1221S, 1992
Little JB, Nove J, Dahlberg WK, Troilo P, Nichols WW, Strong LC: Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni cancer syndrome to DNA-damaging agentsin vitro. Cancer Res 47: 4229–4234, 1987
Bischoff F, Strong LC, Yim SO, Pathak S, Pratt DR, Grant G, Siciliano MJ, Giovanella BC, Tainsky MA: Tumorigenic transformation of spontaneously immortalized fibroblasts from patients with a familial cancer syndrome. Oncogene 6: 183–186, 1991
Malkin D, Li F, Strong LC, Fraumeni JF, Nelson CE, Kim DH, Gryka G, Bischoff FZ, Tainsky MA, Friend SH: Germline p53 mutations in a familial syndrome of sarcomas, breast cancer and other neoplasms. Science 250: 1233–1238, 1990
Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM: Wild type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70: 937–948, 1992
Krizman DB, Giovanella BC, Tainsky MA: Susceptibility for N-ras-mediated transformation requires loss of tumor suppressor activity. Somat Cell Mol Genet 16: 15–27, 1990
Chiao PJ, Kannan P, Yim S, Krizman DB, Wu TA, Gallick GE, Tainsky MA: Susceptibility toras oncogene transformation is coregulated with signal transduction through growth factor receptors. Oncogene 6: 713–20, 1991
Bischoff FZ, Tainsky MA, unpublished data
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Tainsky, M.A., Bischoff, F.Z. & Strong, L.C. Genomic instability due to germline p53 mutations drives preneoplastic Progression toward cancer in human cells. Cancer Metast Rev 14, 43–48 (1995). https://doi.org/10.1007/BF00690210
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DOI: https://doi.org/10.1007/BF00690210