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Effect of muscular exercise on the metabolism of 4-C14 labelled cholesterol in mice

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Conclusions

The effect of exercise on cholesterol metabolism in mice was quantitatively studied after the administration of 4-C14 labelled cholesterol. The distribution of isotope in the sterol and saponifiable fractions of liver and excreta was determined after periods from 3 to 21 days.

It was observed that exercise stimulated [1] the degradation of cholesterol, in particular, its conversion to acidic products, and [2] the excretion of the sterol itself.

From the data obtained it is concluded that this effect of enhanced cholesterol metabolism is obtained only when exercise is continued over a longer period.

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Authors and Affiliations

  1. Laboratoire de l'Effort, University of Brussels, Belgium

    M. Hebbelinck & H. Casier

  2. J. F. & C. Heymans Institute of Pharmacology, University of Ghent, Belgium

    M. Hebbelinck & H. Casier

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  1. M. Hebbelinck
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  2. H. Casier
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Hebbelinck, M., Casier, H. Effect of muscular exercise on the metabolism of 4-C14 labelled cholesterol in mice. Int. Z. Angew. Physiol. Einschl. Arbeitsphysiol. 22, 185–189 (1966). https://doi.org/10.1007/BF00695007

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  • DOI: https://doi.org/10.1007/BF00695007

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