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Sources of heat during nonshivering thermogenesis in Djungarian hamsters: a dominant role of brown adipose tissue during cold adaptation

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Summary

To assess the thermogenic importance of BAT in Djungarian hamsters we removed about 40% of their BAT and compared their thermogenic abilities before and after the operation. BAT was weighed and assayed for its respiratory properties (Cox, mitochondria). Following removal of BAT we observed considerable reductions of NST. The comparison of NST with BAT weight and with respiratory properties of BAT following partial removal of BAT revealed that at least three different pathways for heat production were involved in NST. In cold-adapted hamsters (values for warm-adapted hamsters in parentheses) we estimated that 66.2% (37.0%) of all NST was produced by mitochondrial respiration in BAT; 16.3% (38.4%) was produced in other organ sites but required the presence of BAT, i.e. there was a mediatory action of BAT on thermogenesis in other organ sites. A further 11.5% (23%) of NST occurred outside of and independent of BAT. Mitochondrial respiration in BAT was the only compartment of NST which increased its contribution during cold adaptation (238 mW to 1,062 mW), whereas the other sources of heat remained largely unchanged.

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Abbreviations

BAT :

brown adipose tissue

BATex :

partial removal of brown adipose tissue

BMR :

basal metabolic rate at thermoneutrality

Cox :

cytochrome c oxidase

NA :

noradrenaline

NST :

nonshivering thermogenesis

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Authors and Affiliations

  1. Department of Biology, Philipps-University, D-3550, Marburg, Germany

    Gerhard Heldmaier & Astrid Buchberger

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  1. Gerhard Heldmaier
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  2. Astrid Buchberger
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Heldmaier, G., Buchberger, A. Sources of heat during nonshivering thermogenesis in Djungarian hamsters: a dominant role of brown adipose tissue during cold adaptation. J Comp Physiol B 156, 237–245 (1985). https://doi.org/10.1007/BF00695778

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  • DOI: https://doi.org/10.1007/BF00695778

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