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The development of fast analyzers

Entwicklung schneller Analysatoren

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Summary

New instrumentation has been developed at ORNL for analyzing physiologic specimens. The system is designed for use in clinical laboratories, hospitals, and emergency rooms and for use by researchers. Miniaturized versions may also be used in prolonged space flights.

After consideration of ease of automation, flexibility, and rapid startup, multiple analyses performed in parallel was chosen as the desired approach. Concepts employed in developing the system are discussed, including:

(1) dynamic mixing of samples and reagents through centrifugal transfer from transfer disks into cuvets; (2) rotor design allowing emptying, flushing, and drying of cuvets; (3) precise temperature control; (4) spectrophotometric reaction monitoring; (5) data reduction, with all data stored for possible recall; (6) feedback control for error correction and time saving. Possible future improvements are indicated.

Zusammenfassung

Im Oak Ridge National Laboratory wurde ein neues Analysatorsystem entwickelt, das für die Analyse physiologischer Proben bestimmt ist und in klinischen Laboratorien, Krankenhäusern, Unfallstationen, Forschungsinstituten sowie in einer verkleinerten Version auch in der Raumfahrt zum Einsatz gelangen kann.

Das System zeichnet sich aus durch leichte Automatisierbarkeit, Flexibilität, rasche Inbetriebnahme und eignet sich für parallel durchgeführte Serienanalysen. Die folgenden Charakteristica des Systems werden diskutiert: 1. Dynamisches Mischen von Proben und Reagentien durch zentrifugale Übertragung in die Küvetten, 2. Entleeren, Spülen und Trocknen der Küvetten durch Rotation, 3. Genaue Temperaturkontrolle, 4. Spektrophotometrische Reaktionsüberwachung, 5. Datenberechnung mit Speicherung aller Werte für möglichen Abruf, 6. Feedback-Kontrolle zur Fehlerkorrektur und Zeiteinsparung. Mögliche zukünftige Verbesserungen werden erwähnt.

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Authors and Affiliations

  1. Director Molecular Anatomy Program, Oak Ridge National Laboratory, 37830, Oak Ridge, Tennessee, USA

    Norman G. Anderson

Authors
  1. Norman G. Anderson
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Additional information

The Molecular Anatomy Program is sponsored by the National Institute of General Medical Sciences, the National Cancer Institute, The National Institute of Allergy and Infectious Diseases, and the U.S. Atomic Energy Commission.

Operated for the U.S. Atomic Energy Commission by the Nuclear Division of Union Carbide Corporation.

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Anderson, N.G. The development of fast analyzers. Z. Anal. Chem. 261, 257–271 (1972). https://doi.org/10.1007/BF00786980

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