Abstract
The effect of feeding rats with large doses of vitamin A on the concentration of the polycyclic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) and its metabolites in various organs and in the blood and also on the rate of metabolism in the liver of rats after intravenous injection of the carcinogen were studied. In hypervitaminosis A the quantity of DMBA and its metabolites was found to be considerably reduced in all the organs tested and in the blood. The rate of DMBA metabolism in the liver of the animals increased with an increase in the dose of vitamin A.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
K. L. Kkhandudzha, T. D. Esakova, B. K. Semin, et al., Byull. Éksp. Biol. Med., No. 5, 579 (1977).
E. W. Chu and R. A. Malmgrem, Cancer Res.,25, 844 (1965).
A. H. Conney, Pharmacol. Rev.,19, 317 (1967).
T. L. Dao, C. L. King, and D. Gawlack, J. Nat. Cancer Inst.,40, 157 (1968).
J. Folch, M. Lee, and G. H. Stanley, J. Biol. Chem.,226, 497 (1957).
D. H. Hill and T. W. Shih, Cancer Res.,34, 564 (1974).
C. Huggins, L. Grand, and R. Fukunishi, Proc. Nat. Acad. Sci. USA,51, 737 (1964).
W. G. Levine, J. Pharmacol. Exp. Ther.,183, 420 (1972).
H. Marquardt, T. Kuroki, E. Huberman, et al., Cancer Res.,32, 716 (1972).
P. Sims and P. L. Grover, Biochem. Pharmacol.,17, 1751 (1968).
L. W. Wattenberg and J. L. Leong, Proc. Soc. Exp. Biol. (New York),128, 740 (1968).
L. W. Wattenberg and J. L. Leong, Cancer Res.,30, 1922 (1970).
D. N. Wheatley, Brit. J. Cancer,22, 787 (1968).
Additional information
Deceased.
Rights and permissions
About this article
Cite this article
Kkhandudzha, K.L., Esakova, T.D. & Tarusov, B.N. Role of vitamin a in chemical carcinogenesis of the mammary gland. Bull Exp Biol Med 87, 270–273 (1979). https://doi.org/10.1007/BF00801796
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00801796