Abstract
Blood of normal rabbits and of rabbits on an atherogenic high-cholesterol diet was incubated with sodium acetate-2-[14C]. After incubation, cholesterol and its precursors (squalene and lanosterol) were found and identified in the unsaponified fractions of leukocytes and platelets. Both in normal rabbits and in rabbits with atherosclerosis the highest specific activity in the leukocytes was found in cholesterol, followed by lanosterol and squalene; in the platelets the label accumulated mainly in lanosterol.
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Mironova, V.N., Chayalo, P.P. Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis. Bull Exp Biol Med 86, 1615–1617 (1978). https://doi.org/10.1007/BF00801818
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DOI: https://doi.org/10.1007/BF00801818