Abstract
The character of formation of an experimental syndrome of photogenic epilepsy, obtained by creating a generator of pathologically enhanced excitation in the lateral geniculate body by local injection of tetanus toxin, was studied in chronic experiments on rats. The initial manifestations appearing in the animals were shown to be due to pathological enhancement of specific sensory excitation in the lateral geniculate body and to be accompanied by a marked increase in amplitude of the evoked potential in the visual cortex. The subsequent development of a neuropathological syndrome was connected with diffuse disturbances of rhythmic electrical activity of the brain, characteristic of a state of increased epileptic predisposition in the experimental animals. The results of these experiments indicate an important role of specific and nonspecific factors of epileptogenesis in the formation of experimental photogenic epilepsy.
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Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 87, No. 1, pp. 8–12, January, 1979.
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Konnikov, B.A., Rekhtman, M.B. & Kryzhanovskii, G.N. Pathogenetic factors of experimental photogenic epilepsy. Bull Exp Biol Med 87, 8–12 (1979). https://doi.org/10.1007/BF00802340
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DOI: https://doi.org/10.1007/BF00802340