Abstract
Chitin is an important component of the exoskeleton of arthropods and of the egg shell in nematodes, but it does not occur in vertebrates. Therefore, it represents a useful target for drugs against ectoparasitic crustaceans, insects and endoparasitic nematodes. In this review we describe the basic characteristics of chitin, chitin synthesis and degradation and the hormonal regulation of chitin metabolism. Substances interfering with chitin metabolism like benzoylphenyl-urea derivatives but also some recently detected compounds are described. The necessity for a more detailed understanding of chitin metabolism and the establishment of better model systems, like e.g. chitin producing insect cell lines, is stressed and some examples are given in this review.
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References
Arroyo-Begovich A, Carabez-Trejo A (1982) Location of chitin in the cyst wall ofEntamoeba invadens with colloidal gold tracers. J Parasitol 68:253–258
Arroyo-Begovich A, Carabez-Trejo A, Ruiz-Herrera J (1980) Identification of the structural component in the cyst wall ofEntamoeba invadens. J Parasitol 66:735–741
Aziz MA (1986) Ivermectin vs onchocerciasis. Parasitol Today 2:233–235
Baker TC (1985) Chemical control of behaviour. In: Kerkut GA, Gilbert LI (eds) Comprehensive insect physiology, biochemistry and pharmacology, Vol 9. Pergamon, Oxford, pp 621–672
Calcott PH, Fatig RO (1983) Inhibition of chitin metabolism by avermectin in susceptible organisms. J Antibiot 37:253–259
Campbell WC (1986) Ivermectin: flea, fungi and pharmacology. Parasitol Today 2:75
Campbell WC, Fisher MH, Stapley EO, Albers-Schoenberg G, Jacob TA (1983) Ivermectin: a potent new antiparasitic agent. Science 221:823–828
Chen AC (1987) Chitin metabolism. Arch Insect Biochem Physiol 6:267–277
Cohen E (1987) Chitin biochemistry: synthesis and inhibition. Ann Rev Entomol 32:71–93
Cohen E, Casida JE (1983) Insect chitin synthetase as a biochemical probe for insecticidal compounds. In: Miyamoto J, Kerney PC (eds) Pesticide chemistry/human welfare and the environment. Mode of action — metabolism and toxicology, vol 3. Pergamon, Oxford, pp 25–32
Dubinsky P, Rybos M, Turcekova L (1986a) Properties and localization of chitin synthase inAscaris suum eggs. Parasitology 92:219–225
Dubinsky P, Rybos M, Turcekova L, Ossikovski E (1986b) Chitin synthesis in zygotes ofAscaris suum. J Helminthol 60:187–192
Evans K (1985) An approach to control ofGlobodera rostochiensis using inhibitors of collagen and chitin synthesis. Nematologica 30:247–250
Fuhrman JA, Piessens WF (1985) Chitin synthesis and sheath morphogenesis inBrugia malayi micofilariae. Mol Biochem Parasitol 17:93–104
Fukamizo T, Kramer KJ, Mueller DD, Schaefer J, Garbow J, Jacob GS (1986) Analysis of chitin structure by nuclear magnetic resonance spectroscopy and chitinolytic enzyme digestion. Arch Biochem Biophys 249:15–26
Funke B, Spindler K-D (1987) Developmental changes of chitinolytic enzymes and ecdysteroid levels during the early development of the brine shrimpArtemia In: Declair W, Moens L, Slegers H, Jaspers E, Sorgeloos P (eds)Artemia research and its applications, vol 2. Universa, Wetteren, pp 67–77
Graham-Bryce IJ (1983) Pesticide research for the improvement of human welfare. In: Miyamoto J, Kearney PC (eds) Pesticide chemistry/human welfare. In: Miyamoto J, Kearney PC (eds) Pesticide chemistry/human welfare and the environment. Synthesis and structure-activity relationships, vol 1 Pergamon, New York, pp 21–42
Grosscurt AC, Jongsma B (1987) Mode of action and insecticidal properties of diflubenzuron. In: Wright JE, Retnakaran A (eds) Chitin and benzoylphenyl ureas. Dr W Junk, Dordrecht, pp 75–99
Hajjar NP (1985) Chitin synthesis inhibitors as insecticides. In: Hutson DH, Roberts TR (eds) Insecticides. Progress in pesticide biochemistry and toxicology, vol 5. John Wiley & Sons, New York, pp 275–310
Hansell M (1985) Ethology. In: Kerkut GA, Gilbert LI (eds) Comprehensive insect physiology, biochemistry and pharmacology, vol 9. Pergamon, Oxford, p 1–99
Hepburn HR (1976) The insect integument. Elsevier Scientific, Amsterdam
Jeuniaux C (1982) La chitine dans le régne animal. Bull Soc Zool Fr 107:363–386
Koga D, Isogai A, Sakuda S, Matsumoto S, Suzuki A, Kimura S, Ide A (1987) Specific inhibition ofBombyx mori chitinase by allosamidin. Agric Biol Chem 51:471–476
Kramer KJ, Hopkins TL (1987) Tyrosine metabolism for insect cuticle tanning. Arch Insect Biochem Physiol 6:279–301
Kramer KJ, Dziadik-Turner C, Koga D (1985) Chitin metabolism in insects. In: Kerkut GA, Gilbert LI (eds) Comprehensive insect physiology, biochemistry and pharmacology, vol 3. Pergamon, New York, pp 75–115
Londershausen M, Kammann V, Spindler-Barth M, Spindler K-D, Thomas H (1988) Chitin synthesis in insect cell lines. Insect Biochem 8:631–636
Londershausen M, Spindler-Barth M, Spindler K-D (1989) Influence of the insect growth regulator SIR 8514 on chitin synthesis, chitin degradation and ecdysteroid titer. In: Skjak-Braek G, Anthonsen T, Sandford P (eds) Chitin and Chitosan. Elsevier Applied Science, London, pp 233–242
Marks EP, Leighton T, Leighton F (1982) Modes of action of chitin synthesis inhibitors. In: Coats JR (ed) Insecticide mode of action. Academic Press, New York, pp 281–313
Marks EP, Balke J, Klosterman H (1984) Evidence for chitin synthesis in an insect cell line. Arch Insect Biochem Physiol 1:225–230
Mehlhorn H, Spindler K-D, Spindler-Barth M, Walldorf V, Andrews P, Thomas H (1986) The effect of precocene II and 20-OH-ecdysone onLitomosoides carinii andDipetalonema viteae in vivo. Z Parasitenkd 72:843–845
Miller RW, Miller JA (1985) Feed-through chemicals for insect control in animals. In: Hilton JL (ed) Agricultural chemicals of the future (BARC Symposium), vol 8. Rowman & Allanheld, Totowa, pp 355–363
Muzzarelli RA (1977) Chitin. Pergamon, Oxford
Muzzarelli RA, Jeniaux R, Gooday GW (1986) Chitin in nature and technology. Plenum, New York
Neville AC (1975) Biology of the arthropod cuticle. Springer, Berlin Heidelberg New York
Peter M, Gruen L, Forster H (1984) CP/MS- 13C-NMR spectra of sclerotized insect cuticle and of chitin. Angew Chem Int Ed Engl 23:638–639
Retnakaran A, Wright JE (1987) Control of insect pests with benzoyl ureas. In: Wright JE, Retnakaran A (eds) Chitin and benzoylphenyl ureas. Dr W Junk, Dordrecht, pp 205–282
Retnakaran A, Granett J, Ennis TJ (1985) Insect growth regulators. In: Kerkut GA, Gilbert LI (eds) Comprehensive insect physiology, biochemistry and pharmacology, vol 12. Pergamon, New York, pp 529–601
Reynolds SE (1987) The cuticle, growth and moulting in insects: the essential background to the action of acylurea insecticides. Pestic Sci 20:131–146
Rudall KM, Kenchington W (1973) The chitin system. Biol Rev 49:597–636
Schweikart F, Isogai A, Suzuki A, Peter MG (1989) Inhibition of chitin degrading enzymes in the brine shrimpArtemia salina. In: Skjak-Brack G, Anthonsen T, Sandford P (eds) Chitin and chitosan. Elsevier Applied Science, London, pp 269–278
Spindler K-D (1983) Chitin: its synthesis and degradation in arthropods. In: Scheller K (ed) The larval serum proteins of insects. Thieme, Stuttgart, pp 135–150
Spindler K-D (1988) Parasites and hormones. In: Mehlhorn H (ed) Parasitology in focus/facts and trends. Springer, Berlin Heidelberg New York Tokyo, pp 465–476
Spindler K-D, Spindler-Barth M, Mehlhorn H (1986) Effects of the juvenile hormone antagonist precocene II and the moulting hormone 20-OH-ecdysone onLitomosoides carinii andDipetalonema viteae in vitro. Z Parasitenkd 72:837–841
Spindler-Barth M, Spindler K-D (1987) Antiecdysteroids and receptors. In: Agarwal MK (ed) Receptor mediated antisteroid action. Walter de Gruyter, Berlin, pp 497–511
Spindler-Barth M, Spindler K-D, Londershausen M, Thomas H (1989a) Inhibition of chitin synthesis in an insect cell line. Pestic Sci 25:115–121
Spindler-Barth M, Kammann V, Spindler K-D (1989b) Hormonal regulation of chitin synthesis in two insect cell lines. In: Skjak-Braek G, Anthonsen T, Sandford P (eds) Chitin and chitosan. Elsevier Applied Science, London, pp 279–289
Strong L, Brown TA (1987) Avermectins in insect control and biology: a review. Bull Entomol Res 77:357–389
Veech JA (1978) The effect of diflubenzuron on the reproduction of free living nematodes. Nematologica 24:312–320
Waller PJ, Lacey E (1986) The effect of Triflumuron (SIR 8514) on the free-living stages of sheep nematodes. Vet Parasitol 21:119–126
Ward HD, Alroy J, Lev BJ, Keusch GT, Pereira MCA (1985) Identification of chitin as a structural component ofGiardia cysts. Infect Immun, pp 629–634
Ward KA, Fairbairn D (1972) Chitinase in developing eggs ofAscaris suum (Nematoda). J Parasitol 58:546–549
Wing KD (1988) RH 5849, a nonsteroidal ecdysone agonist: effects on aDrosophila cell line. Science 241:467–469
Wing KD, Slawecki RA, Carlson GR (1988) RH 5849, a nonsteroidal ecdysone agonist: effects on larval Lepidoptera. Science 241:470–472
Wright DJ (1986) Biological activity and mode of action of avermectins. In: Ford MG, Lunt GG, Reay RC, Usherwood PNR (eds) Neuropharmacology and pesticide action. Ellis Horwood, Chichester, pp 174–202 (Ellis Horwood series in biomedicine)
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Dedicated to Prof. Werner Peters (Düsseldorf) for his 60th birthday
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Spindler, KD., Spindler-Barth, M. & Londershausen, M. Chitin metabolism: a target for drugs against parasites. Parasitol Res 76, 283–288 (1990). https://doi.org/10.1007/BF00928180
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DOI: https://doi.org/10.1007/BF00928180