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Synthesis of 4-OXO-5-aminopentanoic acid hydrochloride

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    Selective bromination of 4-oxopentanoic acid in methanol in the presence of urea afforded the 4-oxo-5-bromopentanoic acid methyl ester, a key product for obtaining 4-oxo-5-aminopentanoic acid hydrochloride.

  2. 2.

    Alternatively, 4-oxo-5-aminopentanoic acid hydrochloride was synthesized from 1-phthalimido-3-bromoacetone and Meldrum's acid.

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Literature cited

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    S. I. Zav'yalov & A. G. Zavozin

Authors
  1. S. I. Zav'yalov
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  2. A. G. Zavozin
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 8, pp. 1796–1799, August, 1987.

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Zav'yalov, S.I., Zavozin, A.G. Synthesis of 4-OXO-5-aminopentanoic acid hydrochloride. Russ Chem Bull 36, 1663–1666 (1987). https://doi.org/10.1007/BF00960127

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  • DOI: https://doi.org/10.1007/BF00960127

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