Skip to main content
SpringerLink
Log in

Inhibition of γ-aminobutyric acid release from rat cerebral cortex slices by barbiturate anesthesia

  • Original Articles
  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

Amobarbital and pentobarbital anesthesia inhibited the potassium-stimulated, Ca-dependent release of γ-aminobutyric acid (GABA) from rat cerebral cortex slices during incubation in vitro. Inhibition of GABA release was not found when slices were prepared from rats shortly after they awakened from amobarbital anesthesia. Phenobarbital anesthesia did not affect the release of GABA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Weakley, J. N. 1969. Effect of barbiturates on ‘quantal’ synaptic transmission in spinal motoneurones. J. Physiol. 204:63–77.

    PubMed  Google Scholar 

  2. Richards, C. D. 1971. The selective depression of evoked cortical EPSPs by pentobarbitone. J. Physiol. 217:41P-43P.

    PubMed  Google Scholar 

  3. Nicoll, R. A. 1975. Presynaptic action of barbiturates in the frog spinal cord. Proc. Natl. Acad. Sci. U.S.A. 72:1460–1463.

    PubMed  Google Scholar 

  4. Nicoll, R. A., Eccles, J. C., Oshima, T., andRubia, F. 1975. Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates. Nature 258:625–627.

    PubMed  Google Scholar 

  5. Curtis, D. R., Duggan, A. W., Felix, D., andJohnston, G. A. R. 1971. Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat. Brain Res. 32:69–96.

    PubMed  Google Scholar 

  6. Nicoll, R. A. 1971. Evidence for GABA as the inhibitory transmitter in granule cell inhibition in the olfactory bulb. Brain Res. 35:137–149.

    PubMed  Google Scholar 

  7. Ransom, B. R., andBarker, J. L. 1976. Pentobarbital selectivity enhances GABA-mediated postsynaptic inhibition in tissue cultured mouse spinal neurons. Brain Res. 114:530–535.

    PubMed  Google Scholar 

  8. Cutler, R. W. P., Markowitz, D., andDudzinski, D. S. 1974. The effect of barbiturates on [3H]GABA transport in rat cerebral cortex slices. Brain Res. 81:189–197.

    PubMed  Google Scholar 

  9. Hammerstad, J. P., andCutler, R. W. P. 1972. Sodium ion movements and the spontaneous and electrically-stimulated release of [3H]GABA and [14C]glutamic acid from rat cortical slices. Brain Res. 47:401–413.

    Google Scholar 

  10. Briel, G., Neuhoff, V. andMaier, M. 1972. Microanalysis of amino acids and their determination in biological material using dansylchloride. Hoppe-Seyler's Z. Physiol. Chem. 353:540–553.

    PubMed  Google Scholar 

  11. Cutler, R. W. P., andDudzinski, D. S. 1974. Regional changes in amino acid content in developing rat brain. J. Neurochem. 23:1005–1009.

    PubMed  Google Scholar 

  12. Cutler, R. W. P. 1977. The effect of barbiturates on amino acid release from cerebral cortex. Trans. Am. Soc. Neurochem. 8:207.

    Google Scholar 

  13. Haycock, J. W., Levy, W. B., andCotman, C. W. 1977. Pentobarbital depression of stimulus-secretion coupling in brain—selective inhibition of depolarization-induced calcium-dependent release. Biochem Pharmacol. 26:159–161.

    PubMed  Google Scholar 

  14. Liebowitz, N. R., Pedley, T. A., andCutler, R. W. P. 1987. Release of γ-aminobutyric acid from hippocampal slices of the rat following generalized seizures induced by daily electrical stimulation of entorhinal cortex. Brain Res. 138:369–373.

    Google Scholar 

  15. Blaustein, M. P., andEctor, A. C. 1975. Barbiturate inhibition of calcium uptake by depolarized nerve terminals in vitro. Mol. Pharmacol. 11:369–378.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Stanford University, 94305, Stanford, California

    Dorothy Coleman-Riese & Robert W. P. Cutler

Authors
  1. Dorothy Coleman-Riese
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert W. P. Cutler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Coleman-Riese, D., Cutler, R.W.P. Inhibition of γ-aminobutyric acid release from rat cerebral cortex slices by barbiturate anesthesia. Neurochem Res 3, 423–429 (1978). https://doi.org/10.1007/BF00966324

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00966324

Keywords

Search

Navigation