Skip to main content
SpringerLink
Log in

Inhibition of cyclic-3′,5′-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs

  • Short Communications
  • Published:
Naunyn-Schmiedebergs Archiv für Pharmakologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Bueding, E., Bülbring, E.: The inhibitory action of adrenaline. Biochemical and biophysical observations. In: Bülbring, E.: Pharmacology of smooth muscle, pp. 37–56. Oxford: Pergamon Press 1964.

    Google Scholar 

  • —, Bütcher, R. W., Hawkins, I., Timms, A. R., Sutherland, E. W.: Effect of epinephrine on cyclic adenosine 3′,5′-phosphate and hexose phosphates in intestinal smooth muscle. Biochim. biophys. Acta (Amst.)115, 173–178 (1966).

    Google Scholar 

  • Cheung, W. Y.: Properties of cyclic 3′,5′-nucleotide phosphodiesterase from rat brain. Biochemistry6, 1079–1087 (1967).

    Google Scholar 

  • Dixon, M.: The determinations of enzyme inhibitor constants. Biochem. J.55, 170–171 (1953).

    Google Scholar 

  • Kukovetz, W. R., Juan, H., Pöch, G.: Zum Mechanismus der Papaverinwirkung auf isolierte Coronargefäße. Naunyn-Schmiedebergs Arch. Pharmak.264, 262–263 (1969a).

    Google Scholar 

  • —, Pöch, G.: Cardiostimulatory effects of cyclic 3′,5′-adenosine monophosphate and its acylated derivatives. Naunyn-Schmiedebergs Arch. Pharmak.266, 236–254 (1970).

    Google Scholar 

  • — —: Juan, H.: The role of phosphodiesterase inhibition in the mechanism of coronary dilatation by drugs. In: Abstract of the Fourth Internat. Congress on Pharmacology, p. 170. Basle: Schwabe & Co. 1969b.

    Google Scholar 

  • Moore, P. F., Iorio, L. C., McManus, J. M.: Relaxation of the guinea pig tracheal chain preparation by N6,2′-O-dibutyryl 3′,5′-cyclic adenosine monophosphate. J. Pharm. Pharmacol.20, 368–372 (1968).

    Google Scholar 

  • Pöch, G., Juan, H., Kukovetz, W. R.: Einfluß von herz-und gefäßwirksamen Substanzen auf die Aktivität der Phosphodiesterase. Naunyn-Schmiedebergs Arch. Pharmak.264, 293–294 (1969).

    Google Scholar 

  • Shanes, A. M.: Electrochemical aspects of physiological and pharmacological action in excitable cells. Part I: The resting cell and its alteration by extrinsic factors. Pharmacol. Rev.10, 59–164 (1958a).

    Google Scholar 

  • —: Electrochemical aspects of physiological and pharmacological action in excitable cells. Part II: The action potential and extension. Pharmacol. Rev.10, 165–273 (1958b).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Graz, Austria

    W. R. Kukovetz & G. Pöch

Authors
  1. W. R. Kukovetz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Pöch
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kukovetz, W.R., Pöch, G. Inhibition of cyclic-3′,5′-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs. Naunyn-Schmiedebergs Arch. Pharmak. 267, 189–194 (1970). https://doi.org/10.1007/BF00999402

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00999402

Key-words

Search

Navigation