Skip to main content
SpringerLink
Log in

Regeneration of gastric mucosa after aspirin-induced injury in the rat

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

Regeneration of gastric mucosa damaged by aspirin was studied in 6-week-old rats, using histologic and autoradiographic technics. Aspirin (120 mg/kg) was given by esophageal intubation either in a single dose or each day for 14 days. After a single dose, two types of lesion were observed in the mucosa of the body of the stomach: (a) superficial erosions which were already present after 30 minutes and which completely healed within 24 hours; (b) deeper erosions, reaching maximal numbers at 4 hours, which healed slowly with a median disappearance time of 5 days and which were associated with a focal increase in3H-thymidine-labeled cells. The peak increase in labeling occurred between 16 and 48 hours. The pattern and rate of healing was not altered by repeated daily aspirin. The investigation has demonstrated slow healing of deep mucosal erosions caused by aspirin; the slow healing can be explained by destruction of the progenitor zone by the initial injury.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Roth JLA, Valdes-Dapena A, Pieses P, Buchman E: Topical action of salicylates in gastrointestinal erosion and hemorrhage. Gastroenterology 44:146–158, 1963

    Google Scholar 

  2. Menguy R, Masters YF: Effects of aspirin on gastric mucous secretion. Surg Gynecol Obstet 120:92–98, 1965

    Google Scholar 

  3. Brodie DA, Chase BJ: Role of gastric acid in aspirin-induced gastric irritation in the rat. Gastroenterology 53:604–610, 1967

    Google Scholar 

  4. Davenport HW: Gastric mucosal injury by fatty and acetylsalicylic acids. Gastroenterology 46:245–253, 1964

    Google Scholar 

  5. Geall MG, Phillips SF, Summerskill WHJ: Profile of gastric potential difference in man: effects of aspirin, alcohol, bile and endogenous acid. Gastroenterology 58:437–443, 1970

    Google Scholar 

  6. Smith BM, Skillman JJ, Edwards BG, Silen W: Permeability of the human gastric mucosa: alteration by acetylsalicylic acid and ethanol. N Engl J Med 285:716–721, 1971

    Google Scholar 

  7. Chvasta TE, Cooke AR: The effect of several ulcerogenic drugs on the canine gastric mucosal barrier. J Lab Clin Med 79:302–315, 1972

    Google Scholar 

  8. Hingson DJ, Ito S: Effect of aspirin and related compounds on the fine structure of mouse gastric mucosa. Gastroenterology 61:156–177, 1971

    Google Scholar 

  9. Mowry RW: The special value of methods that color both acidic and vicinal hydroxyl groups in the histochemical study of mucins: with revised directions for the colloidal iron stain, the use of Alcian Blue G8X and their combinations with the Periodic acid-Schiff reaction. Ann NY Acad Sci 106:402–423, 1963

    Google Scholar 

  10. Stevens CE, Leblond CP: Renewal of the mucous cells in the gastric mucosa of the rat. Anat Rec 115:231–245, 1953

    Google Scholar 

  11. Lipkin M, Sherlock P, Bell B: Cell proliferation kinetics in the gastrointestinal tract of man: II. Cell renewal in stomach, ileum, colon and rectum. Gastroenterology 45:721–729, 1963

    Google Scholar 

  12. Dagle GE, Brodie DA, Bauer BG: Comparison of gross and microscopic gastric lesions produced in rats after single doses of aspirin and 2-deoxyglucose. Toxicol Appl Pharmacol 16:638–645, 1970

    Google Scholar 

  13. Williams AW: Observations on the healing of experimental gastric ulcers in small laboratory animals. Br J Surg 41:319–326, 1953

    Google Scholar 

  14. Myhre E: Regeneration of the fundic mucosa in rats: effect of estrone and of castration. Arch Pathol 62:30–36, 1956

    Google Scholar 

  15. Myhre E: Regeneration of the fundic mucosa in rats: V. An autoradiographic study on the effect of cortisone. Arch Pathol 70:476–485, 1960

    Google Scholar 

  16. Hunt TE: Regeneration of the gastric mucosa in the rat. Anat Rec 131:193–211, 1958

    Google Scholar 

  17. Townsend SF: Regeneration of the gastric mucosa in rats. Am J Anat 109:133–147, 1961

    Google Scholar 

  18. Bonfils S, Richir C, Potet F, et al: Ulcère expérimental de contrainte du rat blanc: II. Anatomo-pathologie des lésions gastriques et de différentes lésions viscérales: evolution des ulcérations après cessation de la contrainte. Rev Franc Etud Clin Biol 4:888–894, 1959

    Google Scholar 

  19. Max M, Menguy R: Influence of adrenocorticotropin, cortisone, aspirin, and phenylbutazone on the rate of exfoliation and the rate of renewal of gastric mucosal cells. Gastroenterology 58:329–336, 1970

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Monash University Department of Medicine, Alfred Hospital, Commercial Road, 3181, Melbourne, Australia

    N. D. Yeomans MB, MRACP,  D. J. B. St. John MB, FRACP, MRCP & W. G. R. M. de Boer MD, FRCPA, MC(Path)

  2. Department of Pathology, Repatriation General Hospital, Perth, Australia

    N. D. Yeomans MB, MRACP,  D. J. B. St. John MB, FRACP, MRCP & W. G. R. M. de Boer MD, FRCPA, MC(Path)

Authors
  1. N. D. Yeomans MB, MRACP
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. J. B. St. John MB, FRACP, MRCP
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. G. R. M. de Boer MD, FRCPA, MC(Path)
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by the National Health and Medical Research Council and the Alfred Hospital.

Presented in part to the Australian Society for Medical Research, December 1971.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yeomans, N.D., St. John, D.J.B. & de Boer, W.G.R.M. Regeneration of gastric mucosa after aspirin-induced injury in the rat. Digest Dis Sci 18, 773–780 (1973). https://doi.org/10.1007/BF01070847

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01070847

Keywords

Search

Navigation