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The gastric mucosal response to acetylsalicylic acid in the ferret

An ultrastructural study

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Abstract

An electron microscopic investigation was undertaken on adult fasted ferrets in order to clarify the acute gastric mucosal, morphologic response to orally ingested acetylsalicylic acid. A single, clinically relevant dose (10 mg/kg) was administered and gastric surface responses were studied by scanning electron microscopy, and differential early, cytologic responses of the glandular cells were evaluated by transmission electron microscopy. Gastric bleeding was derived from minute, surface erosions morphologically indistinct from stress-type erosions. Parietal cells underwent drug-specific changes and chief cells, nonspecific degenerative changes. Mucous epithelial cells were disrupted only in localized regions, and tight junctions between surface epithelial cells remained intact. The order of decreasing cellular sensitivity to this acute (10–45 min) exposure to HCl-acidified aspirin solution was: parietal cells, chief cells, and surface epithelial cells. Argentaffin cells and mucous neck cells were resistant.

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Authors and Affiliations

  1. Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

    Carl J. Pfeiffer PhD & Josef Weibel

  2. Institute of Gastroenterology, Presbyterian-University of Pennsylvania, Medical Center, Philadelphia, Pennsylvania

    Carl J. Pfeiffer PhD & Josef Weibel

Authors
  1. Carl J. Pfeiffer PhD
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  2. Josef Weibel
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Additional information

This study was supported in part by the William H. Rorer Gastroenterology Research Fund.

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Pfeiffer, C.J., Weibel, J. The gastric mucosal response to acetylsalicylic acid in the ferret. Digest Dis Sci 18, 834–846 (1973). https://doi.org/10.1007/BF01073333

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  • DOI: https://doi.org/10.1007/BF01073333

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