Abstract
The effect on gastric mucosa of chronic administration of ethanol in excessive amounts was studied electron microscopically in nutritionally replete dogs. Point volumetric analysis was performed on electron micrographs of a control group and an alcohol-fed group of dogs. The mean volume of oxyntic cells increased threefold. Mitochondria appeared damaged and their mean volume was nearly doubled. The mean number of mitochondria per cell remained unchanged in the alcohol-fed dogs. The vesicotubules of the secretory tubular apparatus assumed a predominantly flattened vesicular conflguration but increased in number approximately threefold. Zymogenic cells appeared unchanged. These alterations in electron microscopic morphology suggest that the oxyntic cell is quite susceptible to ethanol, and that the previously reported increase in maximal acid output results from mitochondrial hypertrophy and vesicotubular hyperplasia.
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This work was supported in part by NIMH Grants 20967 and 21462.
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Lillibridge, C.B., Yoshimori, M. & Chey, W.Y. Observations on the ultrastructure of oxyntic cells in alcohol-fed dogs. Digest Dis Sci 18, 443–454 (1973). https://doi.org/10.1007/BF01076593
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DOI: https://doi.org/10.1007/BF01076593