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Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells

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Summary

This report summarizes data on the induction, repair and biological relevance of five types of radiation-induced DNA lesions for which repair kinetic studies have been performed in eukaryotic cells by various laboratories. These lesions are: DNA-protein crosslinks, base damage, single-strand breaks, double-strand breaks and bulky lesions (clustered base damage in the nm-range). The influence of various factors, such as oxia/anoxia, linear energy transfer of the radiation used, incubation medium, cell cycle stage, thiol content, hyperthermia, on the induction and repair of these lesions is described. Radiation-sensitive cell lines are also included.

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  1. Gesellschaft für Strahlen- und Umweltforschung mbH, Institut für Biophysikalische Strahlenforschung, Paul-Ehrlich Strasse 20, D-6000, Frankfurt 70, Germany

    M. Frankenberg-Schwager

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  1. M. Frankenberg-Schwager
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Paper given at the workshop “Molecular Radiation Biology”. German Section of the DNA Repair Network, München-Neuherberg, 21.–23.3.90

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Frankenberg-Schwager, M. Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells. Radiat Environ Biophys 29, 273–292 (1990). https://doi.org/10.1007/BF01210408

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  • DOI: https://doi.org/10.1007/BF01210408

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